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EC number: 231-209-7 | CAS number: 7446-81-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Sep - 16 Oct 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF Test
- Principle of test: In principle, the methods described in OECD Guideline 401 were used.
- Short description of test conditions: 2 and 5 rats per dose respectively were treated by gavage with preparations of the test substance in 0.5 % CMC.
- Parameters analysed / observed: Group-wise documentation of clinical signs was performed over the 7-day (2000 and 4000 mg/kg bw) and 14-day study period (5000 mg/kg bw), respectively. Body weight was determined before the start of the study, as it was needed for determination of dose, and at test termination. The clinical signs and findings were reported in summary form. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium acrylate
- EC Number:
- 231-209-7
- EC Name:
- Sodium acrylate
- Cas Number:
- 7446-81-3
- Molecular formula:
- C3H3NaO2
- IUPAC Name:
- sodium acrylate
- Details on test material:
- - Name of test material (as cited in study report): Sodium acrylate
- Analytical purity: approx. 99 % (not stabilised)
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier): Dr. Nestler (manufacturer)
- Lot/batch number of test material: not specified
- Purity: approx. 99%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: cool, dry, protected from light
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions (e.g. in the exposure medium) and during storage: stable for 3 month
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Mean weight at study initiation: 191 g (males); 190 g (females)
ENVIRONMENTAL CONDITIONS: no details reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: aqueous suspension in 0.5 % CMC
MAXIMUM DOSE VOLUME APPLIED: 2.0 mL/animal - Doses:
- 2000, 4000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- - 2 animals per sex at 2000, and 4000 mg/kg bw
- 5 animals per sex at 5000 mg/kg bw - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days (2000 and 4000 mg/kg bw) and 14 days (5000 mg/kg bw)
- Frequency of observations and weighing: Body weight determination of groups was performed at test start and termination. Lethality and clinical signs of toxicity were observed daily with the exception of weekends and holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- no statistics were performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred at any dose level.
- Clinical signs:
- other: No clinical signs of toxicity were observed at any dose level.
- Gross pathology:
- At necropsy of survivors, no gross-pathological abnormalities were detected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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