Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 205-381-9 | CAS number: 139-89-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
REACH Regulation 1907/2006 (Annex VIII, 8.4 Column 2) states that appropriate in vivo mutagenicity studies should be considered in those cases of a positive result in any of the in vitro genotoxicity studies. In vivo studies available for structurally related substances are also negative.
Additional information
REACH Regulation 1907/2006 (Annex VIII, 8.4 Column 2) states that appropriate in vivo mutagenicity studies should be considered in those cases of a positive result in any of the in vitro genotoxicity studies. In vitro investigations were negative and in vivo studies available for structurally related substances are also negative, so performance of additional in vivo studies is regarded as inappropriate and not in line with current concerns regarding animal welfare and the use of animals in scientific experiments.
Also confirmed by Scientific Bodies (EU RAR, 2004; SCOEL, 2009; EFSA, 2010, 2016).
Justification for classification or non-classification
Non-classification is justified on the basis of negative findings in the Ames tests and in separate in vitro and in vivo tests for gene mutation / mutagenicity with structuraly related substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
