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EC number: 204-884-0 | CAS number: 128-39-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-06-18 to 1988-06-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study (GLP)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- See methods section
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA (Fed Reg v50,188, section 796.1860, 27 Sept 1985
- Deviations:
- yes
- Remarks:
- See methods section
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 3.99 mg/L
- Temp.:
- 25 °C
- pH:
- 5
- Water solubility:
- 4.11 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Water solubility:
- 4.69 mg/L
- Temp.:
- 25 °C
- pH:
- 9
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
- Executive summary:
The purpose of this study was to determine the water solubility of 2,6-di-tert-butylphenol (2,6-DTBP) at pH 5, 7, and 9 using the water column generator method. The water solubility of 2,6-DTBP in water (25±0.5°C) at pH 5, 7, and 9 is as follows:
pH 5
pH 7
pH 9
Solubility (mg/L)
3.99
4.11
4.69
Standard deviation
0.40
0.46
0.32
Number of analyses
16
14
12
Reference
Results:
For the water solubility determination at pH 5, samples were taken in duplicate at each time point. The total number of concentration measurements which were included in the mean water solubility at pH 5 was 16, resulting in a mean water solubility of 3.99 mg/L with a standard deviation of 0.40. For the water solubility determination at pH 7, two separate columns were established and analyzed separately with signal determination at each time point for each column. The total number of concentration measurements which were included in the mean water solubility at pH 7 was 14, resulting in a mean water solubility of 4.11 mg/L with a standard deviation of 0.46. For the water solubility determination at pH 9, samples were taken in triplicate at each time point. The total number of concentration measurements which were included in the mean water solubility at pH 9 was 12, resulting in a mean water solubility of 4.69 mg/L with a standard deviation of 0.32.
Analytical results for the water solubility determination of 2,6-di-tert-butylphenol at pH 5. The column was allowed to equilibrate for 5 minutes at 1 mL/min before samples were taken for analysis. |
|
Time after equilibration in minutes |
Concentration of 2,6-DTBP in mg/L |
0 |
4.75 |
0 |
4.10 |
10 |
3.03 |
10 |
4.17 |
25 |
3.69 |
25 |
3.61 |
40 |
4.31 |
40 |
4.07 |
55 |
4.18 |
55 |
4.10 |
70 |
4.26 |
70 |
3.83 |
100 |
4.17 |
100 |
3.40 |
160 |
4.09 |
160 |
4.07 |
Mean = 3.99 mg/L (n=16) Standard deviation = 0.40 |
Analytical results for the water solubility determination of 2,6-di-tert-butylphenol at pH 7. The column was allowed to equilibrate for 5 minutes at 1 mL/min before samples were taken for analysis. |
|
Time after equilibration in minutes |
Concentration of 2,6-DTBP in mg/L |
0 |
37.6a |
0 |
3.30 |
10 |
3.63 |
10 |
4.23 |
20 |
3.73 |
20 |
4.20 |
30 |
3.30 |
30 |
4.10 |
40 |
4.14 |
40 |
4.35 |
60 |
4.34 |
75 |
4.69 |
90 |
4.34 |
100 |
4.59 |
120 |
2.46b |
120 |
4.66 |
137 |
3.58b |
Mean = 4.11 mg/L (n=14) Standard deviation = 0.46 |
|
a– not included in the mean because test material was probably supersaturated. b– not included in the mean because test material probably depleted by this time on this column. Two separate columns were run for this pH. |
Analytical results for the water solubility determination of 2,6-di-tert-butylphenol at pH 9. The column was allowed to equilibrate for 5 minutes at 1 mL/min before samples were taken for analysis. |
|
Time after equilibration in minutes |
Concentration of 2,6-DTBP in mg/L |
0 |
3.96 |
0 |
4.53 |
0 |
4.54 |
15 |
4.66 |
15 |
4.73 |
15 |
5.17 |
35 |
4.57 |
35 |
4.80 |
35 |
4.86 |
65 |
5.22 |
65 |
4.66 |
65 |
4.63 |
Mean = 4.69 mg/mL (n=12) Standard deviation = 0.32 |
Description of key information
The water solubility of 2,6 -di-tert-butylphenol is 4.11 mg/l at 25°C (pH7).
Key value for chemical safety assessment
- Water solubility:
- 4.11 mg/L
- at the temperature of:
- 25 °C
Additional information
In a Klimisch1 GLP-study the water solubility of 2,6 -di-tert-butylphenol (2,6 -DTBP) was determined at 25°C and at pH 5, 7, and 9 using the water column generator method to be 3.99, 4.11 and 4.69 mg/L, respectively. The results are considered relevant and reliable for the risk assessment.
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