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EC number: 228-601-5 | CAS number: 6303-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- other: alkaline reserve
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Supplement of guidelines 404 and 405 recommends the sequential testing strategy (including pH and alkaline reserve measurements) prior to undertaking the in vivo tests corrosion/irritation of the substance.
The method used in the study which permits the measurement of pH and Alkaline reserve to identify chemicals potentially corrosive to the skin and to the eye was described in V.Froment (1993) and JF.Regnier & C. Imbert (1992), respectively.
Criteria for eye irritation:
The test item is considered at potentially severely irritant to the eye if at least 2 of the 3 following criteria are fulfilled:
- pH <= 2,5 / pH >= 9,5
- log R >= 0, with the R corresponding to the alkaline reserve
- I >= 9, with the I corresponding to the physicochemical index, defined as a weighting of the pH by the decimal logarithm of the Alkaline reserve
I = pH + log R for pH >= 7
I = (14 - pH) + log R for pH < 7
Criteria for skin corrosion :The test item is corrosive to the skin if at least 2 of the 3 following criteria are fulfilled:
- pH <= 2,5 or pH >= 9,5
- log R >= 0
- I >= 10 - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phosphinic acid
- EC Number:
- 228-601-5
- EC Name:
- Phosphinic acid
- Cas Number:
- 6303-21-5
- Molecular formula:
- H3O2P
- IUPAC Name:
- phosphinic acid
- Test material form:
- other: aqueous solution
- Details on test material:
- Sample designation:
- Name of test material: Phosphinic acid
- Physical state: clear liquid
- Date of reception in the test facility: 2009.12.23
- Expiration date of the test item: December 2011
- Batch number: 08-27
- Other characteristics:
relative density at 20°C: 1.2662
purity: 61%
water solubility: soluble (20°C) according to SDS
Certificate of analysis :
- Analysis number: 2009-03075-001
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: pH, alkaline reserve R, physicochemical index I
- Basis:
- other: pH, alkaline reserve R, physicochemical index I
- Time point:
- other: pH
- Score:
- 0.71
- Remarks on result:
- other: for 100g/L solution in water
- Irritation parameter:
- other: pH, alkaline reserve R, physicochemical index I
- Basis:
- other: pH, alkaline reserve R, physicochemical index I
- Time point:
- other: alkaline reserve R
- Score:
- 38.015
- Remarks on result:
- other: log R = 1.580
- Irritation parameter:
- other: pH, alkaline reserve R, physicochemical index I
- Basis:
- other: pH, alkaline reserve R, physicochemical index I
- Time point:
- other: physicochemical index I
- Score:
- 14.87
- Irritant / corrosive response data:
- Under the test conditions, the aqueous phosphinic acid shows an acidic character demonstrated by a pH of 0.71 for a 100 g/L solution in water, analkaline reserve of 38,015 (i.e log R = 1,580) and a physicochemical index of 14,870.
According to the method, the test item is considered:
- as potentially corrosive to the skin as the 3 criteria are fullfilled.
pH <= 2,5 or pH >= 9,5
log R >= 0
I >= 10
- as potentially severely irritant to the eye as the 3 criteria are fullfilled.
pH <= 2,5 or pH >= 9,5;
log R >= 0
I >= 9
As the 3 criteria are fullfilled for both end-points, hypophosphorous acid can be considered as potentially corrosive to the skin and severely irritant to the eye.
Any other information on results incl. tables
Under the test conditions, the aqueous phosphinic acid shows an acidic character demonstrated by a pH of 0.71 for a 100 g/L solution in water, an alkaline reserve of 38.015 (i.e log R = 1.580) and a physicochemical index of 14.870.
Table 1 : Results of neutralization experiments
|
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- According to the method, the test item is considered:
- as potentially corrosive to the skin as the 3 criteria are fullfilled.
pH <= 2,5 or pH >= 9,5
log R >= 0
I >= 10
- as potentially severely irritant to the eye as the 3 criteria are fullfilled.
pH <= 2,5 or pH >= 9,5;
log R >= 0
I >= 9
As the 3 criteria are fullfilled for both end-points, phosphinic acid can be considered as potentially corrosive to the skin and severely irritant to the eye. - Executive summary:
The pH and Alkaline reserve of the test item phosphinic acid was measured according to the method described in the two following references JF.Regnier and C.Imbert (1992), and V.Froment (1993).
Criteria for eye irritation:
The test item is considered at potentially severely irritant to the eye if at least 2 of the 3 following criteria are fulfilled:
- pH <= 2,5 / pH >= 9,5
- log R >= 0, with the R corresponding to the alkaline reserve
- I >= 9, with the I corresponding to the physicochemical index, defined as a weighting of the pH by the decimal logarithm of the Alkaline reserve
I = pH + log R for pH >= 7
I = (14 - pH) + log R for pH < 7
Criteria for skin corrosion :
The test item is corrosive to the skin if at least 2 of the 3 following criteria are fulfilled:
- pH <= 2,5 or pH >= 9,5
- log R >= 0
- I >= 10
This method can be used at first step of stepwise strategy for assessing cutaneous and ocular irritation.
An amount of the test substance is added to distilled water in a beaker. The solution or suspension is maintained for 4 hours with agitation at 37° C. The pH is directly measured and the sample is then titrated with diluted sodium hydroxide or hydrochloric acid until neutrality is obtained. The acidic or alkaline reserve (R) is expressed as the number of grams of pure acid or base necessary to neutralise 100 g of product (%).
A preliminary titration was performed for a preliminary test to allows good conditions for the alkaline reserve (R) determination: 10 mL volume of a 100 g/L solution are neutralised by approximately 95 mL of 0.1 N NaOH. Then for a definitive test, the titration were performed three times more in the same conditions.
Under the test conditions, the aqueous phosphinic acid shows an acidic character demonstrated by a pH of 0.71 for a 100 g/L solution in water, an alkaline reserve of 38.015 (i.e log R = 1.580) and a physicochemical index of 14.870.
According to the method described, as all the criteria are fullfilled, Phosphinic acid can be considered as potentially corrosive to the skin and severely irritant to the eye.
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