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EC number: 222-733-7 | CAS number: 3590-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The following information is available for the acute oral toxicity endpoint:
Prinsen, (2003). Tetraoctylstannane [CAS # 3590-84-9]: acute oral toxicty study with rats, Testing laboratory: TNO Nutrition and Food research. Report no.: V 4410/18. Owner company: Organotin Environmental Programme (ORTEP) Association Stabilizer Task Force.
Kopp, Gunzel, Richter (1973). Systemische Vertraglichkeitsprufung (DL50) nach einmaliger Verabreichung von ZK. 44.682 and Ratten. Testing laboratory: Schering AG. Report no.: Prot. Nr. 3532. Report date: 1973-04-19.
Prinsen, (2003), is presented as the key information as the reliability rating for this study is 1, according to the criteria of Klimisch, 1997, and so is the most reliable study.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity: oral route
In the Prinsen, (2003) study, a sample of Tetraoctylstannane [CAS # 3590-84-90] was examined for acute oral toxicity in an experiment with female rats (limit testing) according to OECD Guideline no. 423.No mortality or clinical signs were observed after treatment with a 300 or a 2000 mg/kg b.w. dose level. Macroscopic examination of the surviving animals at the end of the observation period did not reveal any treatment-related gross changes.
Since all animals survived the 2000 mg/kg dose level, the oral LD50 of Tetraoctylstannane is considered to be higher than 2000 mg/kg body weight.
Kopp, Günzel, Richter (1973), is presented as supporting information only. The LD50 was given as > 4.0 g/kg (> 4000 mg/kg) which corroborates the results of the key study..
Acute toxicity: Dermal and Inhalation routes
No data have been provided for the dermal and inhalation routes as the substance is regarded as a transported isolated intermediate and is used under strictly controlled conditions in line with Article 18, 4.(b) of the REACH regulation EC/1907/2006 which states "procedural and control technologies shall be used that minimise emission and any resulting exposure". As such, only the data specified in Annex VII of the REACH regulation, in accordance with Article 18 (3), is required and it was considered unnecessary to generate additional data via the dermal and inhalation routes of exposure.
As the substance is being registered as a transported isolated intermediate, a CSR is not needed for the registration and thus DNEL values have not been calculated.
Justification for classification or non-classification
The key parameter chosen for acute toxicity for the oral route was greater than the criteria set out in Directive 67/548/EEC and also Regulation (EC) no 1272/2008, therefore classification for acute toxicity was not considered to be necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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