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EC number: 201-116-6 | CAS number: 78-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Conclusion:
Overall the test substance was found to be of low acute toxicity in oral, inhalation and dermal experiments.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP study.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- Other: acute toxicity, oral, rat
- GLP compliance:
- not specified
- Test type:
- other: Acute toxicity: oral
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
- Route of administration:
- oral: unspecified
- Vehicle:
- other: oil (not specified)
- Details on oral exposure:
- no data
- Doses:
- 2,5; 5,0; 10,0 ccm/kg bw.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 other: ccm/kg bw
- Remarks on result:
- other: corresponds to 9260 mg/kg at a density of 0.926 g/cm³
- Mortality:
- no mortalities
- Clinical signs:
- other: diminuated general condition
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of this substance to the rat was determined to be >9,260 mg/kg bw.
- Executive summary:
In an acute oral toxicity study the test substance was administered to white male rats. The animals showed only reduced general condition, but no specific signs of intoxication or mortalities. The doses tested were: 2.5; 5.0; 10.0 ccm/kg bw. The LD50 was >10.0 ccm/kg bw (corresponds to 9260 mg/kg at a density of 0.926 g/cm³)
Reference
In an acute oral toxicity study the test substance was administered to white male rats.
The animals showed only a diminuated general condition, but no signs of intoxication or mortalities.
The doses tested were: 2.5; 5.0; 10.0 ccm/kg bw. The LD50 was >10.0 ccm/kg bw (corresponds to 9260 mg/kg at a density of 0.926 g/cm³).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- >= 9 290 mg/kg bw
- Quality of whole database:
- The database for acute oral toxicity meets the minimum information requirements under REACH Annex VII, with reliable studies used for the endpoint.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No OECD guideline or GLP defined, no analytical tests performed.
- Principles of method if other than guideline:
- other: Acute Toxicity, inhalation in rats
- GLP compliance:
- no
- Test type:
- other: Acute Toxicity, inhalation in rats
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Remarks on duration:
- Durations from 30 minutes up to 210 minutes were tested.
- Concentrations:
- 298, 287, 283, 452, 457, 447 mg/m³ air
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 447 mg/m³ air
- Exp. duration:
- 4 h
- Executive summary:
In an old and limited documented acute inhalation toxicity study in Wistar rats, the animals in groups of ten each were given single exposures of test substance aerosol having a mass medium diameter of 1.5µ. The concentrations given were followed: 298 (60min), 287 (120 min), 283 (180 min), 452 (150 min), 457 (180 min), 447 mg/m³ air (210 min). No mortalities were observed and therefore the LC50 was >447 mg/m³ air.
Reference
Results:
Species: rats (mortalities/No Total) | Concentration (mg/m³ air) | Duration (min) | Product (mg min) |
0/10 | 298 | 60 | 17900 |
0/10 | 287 | 120 | 34400 |
0/10 | 283 | 180 | 51000 |
0/10 | 452 | 150 | 67800 |
0/10 | 457 | 180 | 82200 |
0/10 | 447 | 210 | 93800 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- > 447 mg/m³ air
- Physical form:
- inhalation: aerosol
- Quality of whole database:
- The database for acute oral toxicity meets the minimum information requirements under REACH Annex VII, with reliable studies used for the endpoint.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- A valid waiver is used for this study, in accordance with REACH Annex VIII, Section 8.5.3, Column 2.
Additional information
Acute Toxicity: Oral
In an acute oral toxicity study the test substance was administered to white male rats. The animals showed only reduced general condition, but no specific signs of intoxication or mortalities. The doses tested were: 2.5; 5.0; 10.0 ccm/kg bw. The LD50 was >10.0 ccm/kg bw (corresponds to 9260 mg/kg at a density of 0.926 g/cm³) (Kimmerle, Bayer AG, 1958).
In an acute oral toxicity study according to OECD TG 401 and GLP, 5 female and 5 male SD rats were treated once with a dose of 2000 mg/kg bw of test substance. During the course of the study, no deaths occurred in both male and female groups, and no abnormalities that could be attributed to treatment with the test substance were detected in terms of general conditions, change in body weight and pathological examination. The LD50 in male and female rats therefore was >2000 mg/kg bw (CIPC Japan, 1995).
Acute Toxicity: Inhalation
In an old and limited documented acute inhalation toxicity study in Wistar rats, the animals in groups of ten each were given single exposures of test substance aerosol having a mass medium diameter of 1.5 nm. The concentrations given were followed: 298 (60min), 287 (120 min), 283 (180 min), 452 (150 min), 457 (180 min), 447 mg/m³ air (210 min). No mortalities were observed and therefore the LC50 was >447 mg/m³ air (MacFarland, 1966).
In the same laboratory an acute inhalation toxicity study was performed in Hartley guinea pigs, the animals in groups of ten each were given single exposures of test substance aerosol having a mass medium diameter of 1.5 nm. The concentrations given were followed: 450 (30 min), 298 (60 min), 460 (60 min), 287 (120 min), 448 (99 min), 283 mg/m³ air (180 min). The LD 50 was >460 mg/m³ air (MacFarland, 1966).
Acute Toxicity: Dermal
Only limited acute dermal studies are available which are used as supporting information, this endpoint is waived in accordance with REACH Annex VIII, Section 8.5.3, Column 2:
A very limited documented acute dermal toxicity test in female rabbits is available in which different tris(2-ethylhexyl)phosphate test materials (purities not given) were tested at 20 ml/kg bw. Mortality was observed with all 4 samples; 7/10, 5/10, 2/5 and 2/4 respectively (Union Carbide, 1991).
Acute Toxicity: Other Routes
Additionally several other acute studies were performed:
In an acute intravenous toxicity study in New Zealand White rabbits, the animals in groups of six each were given single i.v. injections of the test substance. The following doses were injected: 6.9, 15.4, 36.9, 75.9 and 358.0 mg/kg bw. No deaths occurred in the first four groups; two of the six rabbits received the highest dose died within 24 hours of injection. Therefore the LD50 for i.v. injection was >358.0 mg/kg bw (MacFarland H.N., 1966).
In an acute intra tracheal toxicity study in New Zealand White rabbits, the animals in groups of six each were given single intra tracheal injections of the test substance. The doses given were followed: 36.0, 181.8, 357.3, 690.0, and 1811 mg/kg bw. No deaths occurred at the three lowest doses; the two highest doses caused one death in six rabbits in each case. Therefore the LD50 was >1811 mg/kg bw (MacFarland H.N., 1966). The data from this limited acute intra tracheal study is in agreement with the low acute inhalation toxicity reported by MacFarland et al. (1966).
Justification for classification or non-classification
The substance does not meet the classification criteria for acute toxicity in accordance with Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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