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Diss Factsheets
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EC number: 291-103-1 | CAS number: 90341-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No irritating or corrosive effects
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- since July 05,1983 to July 08,1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliance with international guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG,
- Weight at study initiation: 3 - 4 kg
- Housing: in individual cages in air-conditioned rooms
- Diet : Breeding diet Altromin 2013 - Rabbit (Altromin GmbH, Lage / Lippe), ad libitum
- Water : deionized water, chlorinated water from automatic watering tables, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2°C
- Humidity (%): 55±10%
- Photoperiod (hrs dark / hrs light): 12 hrs cycle dark/light - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: pasted with 0.25 mL PEG400
- Controls:
- not required
- Amount / concentration applied:
- 500 mg pasted with 0.25 mL PEG400 apllied to shaved skin of 2.5 cm x 2.5 cm
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 30 min, 24 h , 48 h , 72 h after removal of the patches
- Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: semi-occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after the 4 hours exposure period
SCORING SYSTEM: according to Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 hrs
- Score:
- 0.1
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0
- Max. score:
- 4
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the experimental conditions described by OECD guidelines for the examination, acute dermal irritation / corrosivity of the substance Remazol Brillant Blue BB is described as not irritating to the skin.
- Executive summary:
The examination, acute dermal irritation / corrosion in rabbits have shown in the experimental conditions described by the OECD guidelines in the patch test that the substance Remazol Brillant Blue BB after 4 hours of exposure is considered to be not irritating to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 05,1983 to July 08,1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliance with enternational guideline.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG,
- Age at study initiation:
- Weight at study initiation: 2,8 - 3,6 kg
- Housing: in a climatizen room , inside a standard cage
- Diet : Altromin 2013 Zuchtdiat , ad libitum
- Water : deionized water with chloride , ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±2°C
- Humidity (%): 55±10%
- Photoperiod (hrs dark / hrs light): 12 hrs cycle dark/light - Vehicle:
- physiological saline
- Remarks:
- to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
100 g
VEHICLE
0.01 mL physiol. saline - Duration of treatment / exposure:
- 24 Hrs
- Observation period (in vivo):
- 72 Hrs
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing : yes, with warm physiol. saline
- Time after start of exposure: 24hrs
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: UV-lght, fluorescein (0.01%) and slit-lamp - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0.2
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The conjunctiva at 1 h was blue discolored.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance did not show any evidence of irritation
- Executive summary:
The substance Remazol Brillant Blau BB has been tested on rabbit eye in experimental condition described on OECD guidelines. The test substance did not cause irritation in rabbit eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The acute dermal irritation / corrosion properties of Reactive Blue 220 in rabbits have been examined according to OECD 404. According to the test results, of the patch test, the test substance is considered to be not irritating to the skin after 4 hours of exposure.
The substance Reactive Blue 220 has been tested in the rabbit eye according to OECD 405. The test substance did not cause irritation in rabbit eyes.
Justification for classification or non-classification
No irritating or corrosive effects were observed in studies for skin or eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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