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Diss Factsheets
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EC number: 203-870-1 | CAS number: 111-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
From animal tests there is evidence that BCEE has a cancerogenic potential.
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
The ATSDR report concludes:
"The principal reason for concern with BCEE is its apparent carcinogenic potential. The most direct evidence indicating that BCEE is carcinogenic is the increased incidence of hepatomas in two strains of mice dosed orally for 80 weeks (Innes et al. 1969). This is supported by limited data indicating that BCEE is mutagenic in some bacterial test systems, although several studies have yielded negative results. On the other hand, increased incidence of mouse liver hepatomas has been questioned as a reliable indication of true carcinogenic potential (Maronpot et al. 1987), and BCEE was not observed to cause a significant increase in tumors in a chronic feeding study in rats (Weisburger et al. 1981) or in parenteral exposure studies in mice (Theiss et al. 1977; Van Duuren et al. 1972) and rats (Norpoth et al. 1986). Also, no binding of BCEE to DNA and no foci of ATPase-deficient cells (a sign of pre-neoplastic effects) were detected in liver of rats exposed to BCEE (Gwinner et al. 1983), and no evidence of heritable chromosome damage was detected in a preliminary study in mice (Jorgenson et al. 1978). Consequently, while the positive carcinogenicity findings in mice are adequate to conclude that BCEE may be a human carcinogen,the evidence on this point is limited."
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