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Diss Factsheets
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EC number: 201-187-3 | CAS number: 79-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Necropsy revealed a significant inhalative coexposure causing severe, extensive hemorrhages of the lung in many animals. Inhalative coexposure may have caused additional deaths.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl chloroformate
- EC Number:
- 201-187-3
- EC Name:
- Methyl chloroformate
- Cas Number:
- 79-22-1
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- methyl chloroformate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF breed: Hagemann, Extertal, Germany
- Weight at study initiation: males: 224 g; females: 183 g
- Fasting period before study:
- Diet: ad libitum; MRH concentrated feed of H . Eggersmann, Rinteln/Weser, Germany,
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 13 .3 cm2; to the clipped skin of the back and flank
- Type of wrap if used: The treated area of skin was then covered with an inert foil, which was secured in position with adhesive tape .
REMOVAL OF TEST SUBSTANCE
- Washing with warm water and dried with cellulose
- Time after start of exposure: after 24 h - Doses:
- 2000; 1000 and 640 mg/kg .
- No. of animals per sex per dose:
- 5 (640 and 2000 mg/kg); 6 (1000 mg/kg)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 894 mg/kg bw
- 95% CL:
- 693 - 1 161
- Mortality:
- After 14 days: 649 mg/kg: females 0/5, males 2/5; 1000 mg/kg: females 5/6, males 2/6; 2000 mg/kg: females 5/5, males 5/5
- Clinical signs:
- Dyspnea, apathy, staggering, cyanosis, tonic convulsions, spastic gait and piloerection
Signs of local irritation : After 24 hours, clear signs of primary irritation ; after 4 days, leathery necroses. - Body weight:
- Mean body weight development of the surviving animals was positive.
- Gross pathology:
- Animals that died: Heart: acute dilatation on the right side; acute passive hyperemia;
lungs: severe, extensive hemorrhages (wet and sarcoid areas) in some cases
Sacrificed animals: Organ : no abnormalities detected
Any other information on results incl. tables
The product was applied once for 24 hours to the clipped skin of the back and flank (area of 13.3 cm2) unchanged in doses of 2,000 ; 1,000 and 640 mg/kg .The median lethal dose ( LD50) for males and females after 14 days was: 894 mg/kg (693 -1,161 mg/kg )
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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