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EC number: 239-183-9 | CAS number: 15123-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Nov - 02 Dec 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with acceptable restrictions (limited documentation: not specified at which concentration precipitation occurred)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- (adopted July 1997)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Version / remarks:
- (adopted May 2008)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55116 Mainz, Germany
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Dodecaaluminium trimolybdenum dodecaoxide
- EC Number:
- 239-183-9
- EC Name:
- Dodecaaluminium trimolybdenum dodecaoxide
- Cas Number:
- 15123-80-5
- Molecular formula:
- Al2Mo3O12
- IUPAC Name:
- dialuminium(3+) tris(dioxomolybdenumbis(olate))
- Details on test material:
- - Name of test material (as cited in study report): Aluminium molybdate
- Physical state/appearance: solid, odourless
- Analytical purity: > 99%
- Lot/batch No.: GRA 2011-10-13-01
- Expiration date of the lot/batch: Nov 2018
- Storage condition of test material: room temperature
Constituent 1
Method
- Target gene:
- his-operon
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA 1535, TA 97a, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- cofactor supplemented post-mitochondrial fraction (S9 mix), prepared from the livers of rats treated with Aroclor 1254
- Test concentrations with justification for top dose:
- Experiment I: 4993, 1503, 499, 152, and 51 µg/plate
Experiment II: 5049, 2511, 1262, 621, and 317 µg/plate - Vehicle / solvent:
- sterile aqua denim.
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- benzo(a)pyrene
- other: 4-Nitro-1,2-phenylene diamine (NPD); 2-amino anthracene (2AA)
- Remarks:
- NPD (20 µg/plate, DMSO): TA97a, TA98, and TA102 (- S9 mix); sodium azide (1 µg/plate, H2O): TA100 and TA1535 (- S9 mix); 2AA (1 µg/plate, DMSO: TA97a, TA100, TA102, and TA1535 (+ S9 mix); Benzo-a-pyrene (20 µg/plate, DMSO): TA98 (+ S9 mix)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation) (experiment II)
DURATION
- Exposure duration: 48 h at 37 °C
METHOD OF APPLICATION: preincubation (experiment II)
- Preincubation time: 20 min
- Exposure duration: 48 h at 37 °C
NUMBER OF REPLICATIONS: four replicates per condition per experiment
DETERMINATION OF CYTOTOXICITY
- Method: reduction of background lawn
A toxicity control was performed analogously to the titre control with test substance concentrations of 5000 and 1500 µg/plate. - Evaluation criteria:
- A test item is considered to have mutagenic potential, if a significant, reproducible increase of revertant colonies per plate (factor >= 2) in at least one strain can be observed. A concentration-related increase over the range tested can also be taken as a sign of mutagenic activity.
Results and discussion
Test results
- Species / strain:
- other: S. typhimurium TA 1535, TA 97a, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Precipitation: No complete dissolution was possible, undissolved particles were visible on the plates. Thus, only the nominal concentration is given. It was not specified in the study report if undissolved particles were seen in all plates or only at higher concentrations.
COMPARISON WITH HISTORICAL CONTROL DATA: Yes; the values for spontaneous revertants and for positive controls were within the range of the historical data. Thus, the study is considered as valid.
ADDITIONAL INFORMATION ON CYTOTOXICITY: No signs of toxicity towards the tested strains were detected. The background lawn was visible and the number of revertant colonies was not reduced.
In both experiments, the sterility control and the determination of the titre did not show any inconsistencies.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 1. Test results of experiment 1 (plate incorporation).
With or without S9-Mix |
Test substance (μg/plate) |
Mean number of revertant colonies per plate (average of 4 plates ± Standard deviation) |
||||
Base-pair substitution type |
Frameshift type |
|||||
TA 100 |
TA1535 |
TA102 |
TA98 |
TA97a |
||
|
H2O |
150 ± 11 |
15 ± 3.6 |
166 ± 9.1 |
10 ± 0.5 |
121 ± 13.5 |
– |
DMSO |
125 ± 6.4 |
15 ± 3.9 |
147 ± 22.1 |
10 ± 0.0 |
99 ± 6.6 |
– |
51 |
117 ± 11 |
16 ± 3 |
173 ± 6 |
11 ± 3 |
116 ± 13 |
– |
152 |
131 ± 12 |
17 ± 2 |
169 ± 13 |
11 ± 3 |
97 ± 6 |
– |
499 |
138 ± 11 |
19 ± 1 |
146 ± 19 |
11 ± 4 |
128 ± 11 |
– |
1503 |
118 ± 11 |
16 ± 1 |
146 ± 16 |
9 ± 2 |
105 ± 11 |
– |
4993 |
122 ± 18 |
17 ± 5 |
158 ± 7 |
10 ± 0 |
111 ± 10 |
Positive controls, –S9 |
Name |
SA |
SA |
NPD |
NPD |
NPD |
Concentrations (μg/plate) |
1 |
1 |
20 |
20 |
20 |
|
Mean No. of colonies/plate (average of 4 ± SD) |
487 ± 109 |
124 ± 12 |
579 ± 86 |
132 ± 14 |
414 ± 68 |
|
|
H2O |
126 ± 15.3 |
17 ± 1.9 |
148 ± 21.3 |
10 ± 0.8 |
126 ± 31.2 |
+ |
DMSO |
137 ± 17.1 |
19 ± 1.7 |
159 ± 8.6 |
10 ± 0.0 |
116 ± 7.5 |
+ |
51 |
113 ± 20 |
14 ± 3 |
172 ± 38 |
13 ± 5 |
111 ± 8 |
+ |
152 |
157 ± 13 |
19 ± 3 |
164 ± 21 |
11 ± 2 |
112 ± 9 |
+ |
499 |
129 ± 17 |
17 ± 3 |
161 ± 26 |
11 ±3 |
111 ± 4 |
+ |
1503 |
135± 30 |
16 ± 1 |
162 ± 8 |
13 ± 3 |
103 ± 13 |
+ |
4993 |
145 ± 11 |
15 ± 1 |
184 ± 33 |
12 ± 4 |
120 ± 15 |
Positive controls, +S9 |
Name |
2AA |
2AA |
2AA |
BP |
2AA |
Concentrations (μg/plate) |
1 |
1 |
1 |
20 |
1 |
|
Mean No. of colonies/plate (average of 4 ± SD) |
444 ± 100 |
111 ± 11 |
621 ± 75 |
117 ± 10 |
376 ± 49 |
NPD = 4-Nitro-1.2-phenylene diamine
SA = Sodium azide
2AA = 2-Aminoanthracene
BP = Benzo(a)pyrene
Table 2. Test results of experiment 2 (pre-incubation).
With or without S9-Mix |
Test substance (μg/plate) |
Mean number of revertant colonies per plate (average of 4 plates ± Standard deviation) |
||||
Base-pair substitution type |
Frameshift type |
|||||
TA 100 |
TA1535 |
TA102 |
TA98 |
TA97a |
||
|
H2O |
100 ± 7.5 |
14 ± 2.9 |
178 ± 20.3 |
16 ± 2.8 |
118 ± 2.2 |
– |
DMSO |
92 ± 5.1 |
12 ± 1.7 |
147 ±8.3 |
15 ± 1.7 |
102 ±4.3 |
– |
317 |
87 ± 13 |
13 ± 4 |
115 ± 4 |
14 ± 3 |
106 ±10 |
– |
621 |
87 ± 9 |
12 ± 2 |
119 ± 5 |
14 ± 1 |
116 ± 5 |
– |
1262 |
101 ± 7 |
14 ± 3 |
156 ± 6 |
13 ±1 |
109 ± 6 |
– |
2511 |
95 ± 7 |
11 ± 2 |
165 ± 19 |
16 ±1 |
114 ±7 |
– |
5049 |
90 ± 11 |
12 ± 2 |
165 ± 7 |
14 ± 3 |
106 ± 7 |
Positive controls, –S9 |
Name |
SA |
SA |
NPD |
NPD |
NPD |
Concentrations (μg/plate) |
1 |
1 |
20 |
20 |
20 |
|
Mean No. of colonies/plate (average of 4 ± SD) |
513 ± 38 |
230 ± 25 |
635 ± 51 |
221 ± 15 |
475 ± 68 |
|
(Second value*) |
294 ± 108 |
|
473 ± 175 |
|
|
|
|
H2O |
86 ± 8.5 |
13 ± 2.2 |
155 ± 8.7 |
15 ± 3.9 |
112 ±5.5 |
+ |
DMSO |
88 ± 11.8 |
11 ± 2.2 |
159 ± 8.7 |
14 ± 2.9 |
110 ±2.2 |
+ |
317 |
84 ± 8 |
15 ± 3 |
111 ± 11 |
14 ± 2 |
128 ± 6 |
+ |
621 |
89 ± 13 |
15 ± 2 |
111 ± 9 |
13 ± 3 |
115 ±4 |
+ |
1262 |
86 ± 9 |
14 ± 3 |
170 ± 23 |
16 ± 2 |
108 ±7 |
+ |
2511 |
85 ± 9 |
14 ± 4 |
154 ± 14 |
14 ± 2 |
110 ±6 |
+ |
5049 |
90 ± 10 |
15 ± 2 |
148 ± 9 |
14 ± 2 |
102 ± 8 |
Positive controls, +S9 |
Name |
2AA |
2AA |
2AA |
BP |
2AA |
Concentrations (μg/plate) |
1 |
1 |
1 |
20 |
1 |
|
Mean No. of colonies/plate (average of 4 ± SD) |
472 ± 144 |
217 ± 15 |
612 ± 72 |
242 ± 22 |
554 ±23 |
NPD = 4-Nitro-1.2-phenylene diamine
SA = Sodium azide
2AA = 2-Aminoanthracene
BP = Benzo(a)pyrene
* Two different values were calculated in these cases, because the raw data were recorded in a way that could be interpreted in different ways.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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