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EC number: 252-038-4 | CAS number: 34452-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
KTG is toxic by ingestion (Acute Tox 3).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05-June-2000 - 19-July-2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Male and female Sprague Dawley rats CD (Crl: CD (SD) IGS BR)
- Supplier: Charles River (UK) Ltd, Margate, Kent, UK
- Weight: 221-229 g (M), 202-232 g (F)
- Age: 12 weeks
- Acclimatization: at least 5 days
- Housing: groups of 3 by sex in solid-floor polypropylene cages
- Diet: ad libitum except fasting (Rat and Mouse Expanded Diet N°1, Special Diets Services Limited, Witham, Essex, UK)
- Water: drinking water ad libitum
- Fasting: overnight before dosing and 3-4 hours after dosing
CONDITIONS:
- Temperature: 19-25 °C
- Relative Humidity: 30-70 %
- Air changes: approx. 15/hour
- Dark-Light cycle (hours): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 200, 500 and 2000 mg/kg potassium thioglycolate as 42.5% solution.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- All animals were dosed once only by gavage. The animals were observed for death or overt signs of toxicity 1/2, 1, 2 and 4 hours after dosing and subsequently twice daily for up to 14 days. Individual body weights were recorded prior to dosing and 7 and 14 days after treatment or at death. At the end of the observation period, animals were subjected to macroscopic examination. No tissue was retained.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 200 - <= 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals treated with 2000 mg/kg, one animal treated with 500 mg/kg and one animal treated with 200 mg/kg were found dead during the day of dosing. The two remaining animals treated with 500 mg/kg were found dead one day after dosing.
- Clinical signs:
- other: Hunched posture was commonly noted at dose levels of 2000 mg/kg, 500 mg/kg and in females treated with 200 mg/kg with lethargy also commonly noted at 2000 mg/kg and ataxia also commonly noted at 500 mg/kg. lncidents of decreased respiratory rate and labou
- Gross pathology:
- Abnormalities noted at necropsy of animals that died during the study were haemorrhagic lungs, dark liver, dark kidneys, epithelial sloughing of thegastric mucosa and haemorrhage of the bladder. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral median lethal dose LD50 of potassium thioglycolate 43% solution was estimated to be in the range of 200-500 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 200 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07-Mar-2012 - 28-Aug-2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- French Republic, Prime Minister, Interministerial Group on Chemicals (GIPC)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Breeder: Janvier, Le Genest-Saint-Isle, France
- Age at study initiation: approximately 9 weeks
- Weight at study initiation: 290 ± 7 g for the males and 228 ± 6 g for the females
- Water and food: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 30 to 70
- Ventilation: approximately 12 cycles/hour of filtered, non-recycled air. - Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: a dorsal area of the skin (approximately 5 cm x 6 cm for the females and 5 cm x 7 cm for the males)
- % coverage: approximately 10%
- Type of wrap if used: hydrophilic gauze pad held in contact with the skin by means of an adhesive hypoallergenic aerated semi-occlusive dressing and a restraining bandage
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.64 mL/kg
- Constant volume or concentration used: no - Duration of exposure:
- 24 h
- Doses:
- A single dose of 2000 mg/kg of the test item in its original form was placed on a hydrophilic gauze pad and then applied to the clipped area of the skin.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female, which was accidentally wounded on the removal of the dressing, was killed on day 2 for ethical reasons. No deaths related to treatment occurred during the study.
- Clinical signs:
- other: No clinical signs were observed during the study.
- Gross pathology:
- Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the experimental conditions, the dermal LD50 of KTG is higher than 2000 mg/kg in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- LD50 determined with KTG is >2000 mg/kg bw for rats.
Additional information
Thioglycolic acid and its salts are toxic by oral administration. When expressed as thioglycolate anion, the LD50values of thioglycolic acid and its salts are more or less in the same dose range LD50 ≥ 50 mg/kg a. i. thioglycolate.
Justification for selection of
acute toxicity – oral endpoint
LD50 determined with KTG (ATC method).
Justification for classification or non-classification
Based on acute oral toxicity data in rats.
Classification:
EU-GHS: Acute tox cat. 3. H301. Toxic if swallowed.
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