Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
other: review article
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review article providing general information on cyanide toxicity

Data source

Reference
Reference Type:
secondary source
Title:
Noxious Gases and Vapours I: Carbon Monoxide, Cyanides, Methemoglobin and Sulfhemoglobin
Author:
Reiders, F
Year:
1971
Bibliographic source:
Drill's Pharmacology in Medicine, 4th ed, DePalma, J.R. (ed). New York, NY, McGraw-Hill Book Co., P 1180-1205.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Review of information concerning human exposure and poisoning.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium cyanide
EC Number:
205-792-3
EC Name:
Potassium cyanide
Cas Number:
151-50-8
Molecular formula:
CKN
IUPAC Name:
potassium cyanide
Radiolabelling:
no

Results and discussion

Signs and symptoms of toxicity:
yes
Remarks:
death
Dermal irritation:
not specified
Absorption in different matrices:
Dermal absorption of 100 mg/kg on human skin is associated with death. Fatalities have occurred at skin absorption of 5% cyanide solutions.

Applicant's summary and conclusion

Conclusions:
Human fatalities have been associated with solutions of cyanide salts at 5%. The dermal threshold is 100 mg/kg bw.