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Diss Factsheets
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EC number: 244-742-5 | CAS number: 22036-77-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 July 1981 - 14 August 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A combined irritation and sensitisation study is reported in man, which was conducted according to a scientifically acceptable principle. No mention of GLP is included in the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modified Shelanski Repeated Insult Patch Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- EDTMP-5Na
- IUPAC Name:
- EDTMP-5Na
- Reference substance name:
- Pentasodium trihydrogen [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonate
- EC Number:
- 231-615-4
- EC Name:
- Pentasodium trihydrogen [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonate
- Cas Number:
- 7651-99-2
- Molecular formula:
- C6H15N2O12P4.5Na
- IUPAC Name:
- pentasodium trihydrogen {ethane-1,2-diylbis[nitrilobis(methylene)]}tetrakis(phosphonate)
- Details on test material:
- - Name of test material (as cited in study report): Dequest (R) 2046
- Physical state: Yellow liquid
- pH: 6-8
Constituent 1
Constituent 2
Test animals
- Species:
- human
- Strain:
- other: n/a
- Details on test animals or test system and environmental conditions:
- Not applicable.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- Repeated application, 24h at a time
- Observation period:
- 4 weeks
- Number of animals:
- 56 individuals started; 54 individuals completed the study.
- Details on study design:
- TEST SITE
- Area of exposure: the back
- Type of wrap if used: Specially prepared Parke-Davis Readi-Bandages were used for patching in this study. The treated patch was applied to designated site after application of test material on to it. The adhesive was pressed all around to assure firm contact of the test material with the skin to form a seal to retard the loss of moisture.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- The absence of visible irritation as a result of the application indicates that the material, tested as supplied was incapable of acting as a primary irritant of the immediate type in any of the individuals under the test. The same study assessed both irritation and sensitisation and through applications 2 to 12 only solitary, minimal responses were observed in 3 individuals during this period. In view of the lack of any responses in any of the other individuals under test, the investigator believes that these responses were artifacts and attached no significance to them. The absence of visible irritation during the challenge period further confirmed that the material, tested as supplied, was incapable of acting as a primary irritant of the immediate type in any of the individuals under test.
- Other effects:
- None reported.
Any other information on results incl. tables
0.2 ml of the test material was applied on skin as a 100% solution.
Dequest 2046 is known to have 35.7% active salt content at pH 6 -8, and a specific gravity of 1.3 -1.36 g/ cm3.
The pKa of the salt at pH 7.3 is estimated to be 6. The conversion factor to determine the salt to acid equivalent for mass for EDTMP-6Na salt is 0.768.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- This combined irritation and sensitisation study in man reports no irritant effects of the test material, after a single dose nor after repeated applications. The study was carried out according to a scientifically acceptable protocol.
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