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Diss Factsheets
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EC number: 627-132-7 | CAS number: 1227096-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
One study is recorded for this endpoint and was chosen as a key study. The potential of the substance to induce reverse mutation in bacteria was assessed using five strains of Salmonella typhimurium and Escherichia coli Wp2uvrA according to a method comparable to OECD guideline 471. The study was conducted in compliance with the principles of Good Laboratory Practice.
The substance was tested in two independent experiments, with and without a metabolic activation system, both performed according to the direct plate incorporation method. Bacteria were exposed to the substance at six dose-levels (three plates/dose-level) selected from a preliminary toxicity test. In both experiments, the dose-levels ranged from 4 to 5000 µg/plate for all strains, with and without S9 mix. After 48 to 72 hours of incubation, the revertant colonies were scored.
The number of revertants for the vehicle and positive controls was as specified in the acceptance criteria. The study was therefore considered valid.
The substance did not induce any significant increase in the number of revertants, both with and without S9 mix, in any of the five strains of Salmonella typhimurium and Escherichia coli WP2uvrA.
The substance was considered to be non-mutagenic under the conditions of this test.
Short description of key information:
The potential of the substance to induce gene mutation in bacteria was investigated using a gene mutation assay on Salmonella typhimurium TA 1535, TA 1537, TA1538, TA 98, TA 100 and on E. Coli WP2uvrA (method equivalent to OECD guideline 471, GLP).
The test item was found to be not mutagenic in this assay.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance is not mutagenic in the vitro gene mutation test in bacteria. However and according to the criteria laid down in EU regulation (EC) n° 1272/2008 (CLP) and the EU directive 67/548/EEC, the substance cannot be classified for genetic toxicity on a basis of a sole gene mutation test in bacteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.