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EC number: 200-554-5 | CAS number: 63-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04. to 17. July 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- , doses were 1000 and 500 mg/kg
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Androst-4-ene-3,17-dione
- EC Number:
- 200-554-5
- EC Name:
- Androst-4-ene-3,17-dione
- Cas Number:
- 63-05-8
- Molecular formula:
- C19H26O2
- IUPAC Name:
- androst-4-ene-3,17-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Wistar-Han-Schering
- Source: Schering
- Age at study initiation: not reported
- Weight at study initiation: 105-123 g
- Fasting period before study: about 19 h
- Housing: singly in conventional housing conditions
- Diet and water: ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23
- Humidity (%): 48-60
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: physiological saline containing 0.085 % Myrj 53
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 mg/ml
- Doses:
- 500 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 3 males/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for clinical signs thrice on day 1 (30 min., 1 h, and 2 h after substance sdministration), twice on day 2 (in the morning and in the afternoon), and at least once daily throughout the rest of the study. Body weights were determined at study start (day 1), on day 7 and at termination of the study (day 14).
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All three animals of dose group 1000 mg/kg died on day 3 of the study. No mortalities were observed after administration of 500 mg/kg.
- Clinical signs:
- other: Compound-related clinical signs were apathy, disturbance of gait and squatting position. In addition prone position, unconsciousness, disturbance in respiration and increased diuresis were observed at lethal dose (1000 mg/kg). The surviving animals were w
- Gross pathology:
- Macroscopic findings in animals which died before the end of the observation period were paleness of liver and kidneys and black-brown foci in glandular mucosa of stomach. Animals at the dose of 500 mg/kg were without macroscopic pathological findings.
Applicant's summary and conclusion
- Conclusions:
- The single oral administration of the substance to male rats caused mortality at 1000 mg/kg in 3/3 animals on Day 3 of the study, whereas all three animals survived at 500 mg/kg. Compound-related clinical signs were apathy, disturbance of gait and squatting position and, additionally at lethal dose, prone position, unconsciousness, disturbance in respiration and increased diuresis. All surviving animals were without clinical signs from Day 2 up to the end of the 14 -day observation period. Macroscopic findings in animals which died prematurely were paleness of liver and kidneys and black-brown foci in glandular mucosa of stomach. Animals at the dose of 500 mg/kg were without macroscopic pathological findings. Thus, the LD50 after oral administration to male rats was concluded to be between 500 and 1000 mg/kg bw
- Executive summary:
In an acute oral toxicity study similar to OECD TG 423, fasted Wistar rats (3 males/dose) were given a single oral dose by gavage of Androstendione in physiological saline with 0.085% (w/v) Myrj 53 at doses of 500 and 1000 mg/kg bw and observed for 14 days.
Mortality was observed at 1000 mg/kg bw in 3/3 animals on Day 3 of the study, whereas all three animals survived at 500 mg/kg bw. Compound-related clinical signs were apathy, disturbance of gait and squatting position and, additionally at lethal dose, prone position, unconsciousness, disturbance in respiration and increased diuresis. All surviving animals were without clinical signs from Day 2 up to the end of the 14 -day observation period. Macroscopic findings in animals which died prematurely were paleness of liver and kidneys and black-brown foci in glandular mucosa of stomach. Animals at the dose of 500 mg/kg were without macroscopic pathological findings. Thus, the LD50 after oral administration to male rats was concluded to be between 500 and 1000 mg/kg bw.
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