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Diss Factsheets
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EC number: 220-250-6 | CAS number: 2687-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP study and non-guideline study, but basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- similar to OECD 401
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-ethylpyrrolidin-2-one
- EC Number:
- 220-250-6
- EC Name:
- 1-ethylpyrrolidin-2-one
- Cas Number:
- 2687-91-4
- Molecular formula:
- C6H11NO
- IUPAC Name:
- 1-ethylpyrrolidin-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): N-ethylpyrrolidon
- Molecular weight : 113
- Physical state: liquid
- Analytical purity: > 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The mean body weights for males was 208 g and for females 165 g.
The animals were offered Herilan MRH concentrated feed and water ad libitum. Feed was withdrawn 16 hours before the beginning of the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 10.0; 21.5; 31.6 and 50% solution in distilled water in doses of 1,000; 2,150; 3,160 and 5,000 mglkg
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 200 mg/kg bw
- Mortality:
- see below
- Clinical signs:
- other: see below
- Gross pathology:
- Animals that died: Heart: acute dilatation; kidneys: some of them pale; lungs: infarctoid congestion with edematization; intestines: atonic
Sacrificed animals: Organs: no abnormalities detected
Any other information on results incl. tables
Mortality:
Dose (mg/kg) | Conc. (%) | No. of animals | Died within | ||||
1 hour | 24 hours | 48 hours | 7 days | 14 days | |||
5,000 | 50 | 5 males | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 |
5 females | 0/5 | 3/5 | 4/5 | 4/5 | 4/5 | ||
3,160 | 31.6 | 5 males | 0/5 | 0/5 | 1/5 | 1/5 | 1/5 |
5 females | 0/5 | 2/5 | 4/5 | 4/5 | 4/5 | ||
2,150 | 21.5 | 5 males | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
5 females | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | ||
1,000 | 10.0 | 5 males | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
5 females | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Symptoms:
5,000 mg/kg | 3,160 mg/kg | 2,150 mg/kg | 1,000 mg/kg | |
Dyspnea | 15 min - 6 d | < 15 min - 4 h | 1 h - 5 h | |
Apathy | 15 min - 5 d | < 15 min - 4 h | 1 h - 5 h | |
Lateral position | 1 h - 2 d | 30 min - 4 h | ||
Abdominal position | 30 min - 4 h | 2 h - 4 h | ||
Dorsal position | 4 h | |||
Staggering | 15 min - 1 d | < 15 min - 4 h | ||
Atony | 1 h - 4 h | |||
Paresis | 15 min - 2 d | |||
Pain reflex absesnt | 1 h | |||
Narcotic-like state | 1 h | |||
Urine orange | 1 d - 5 d | |||
Erythema | 1 h - 2 d | |||
Exsiccosis | 1 h - 2 d | |||
Ames blood test | 15 min - 6 d | < 15 min - 4 h | 1 h - 5 h |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.