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Diss Factsheets
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EC number: 201-194-1 | CAS number: 79-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- other: BASF-test
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutyryl chloride
- EC Number:
- 201-194-1
- EC Name:
- Isobutyryl chloride
- Cas Number:
- 79-30-1
- Molecular formula:
- C4H7ClO
- IUPAC Name:
- 2-methylpropanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Isobuttersäurechlorid
Constituent 1
Test animals
- Species:
- mouse
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 0.25, 0.64, 0.80, 1, 1.25, 1.6, 4, 32 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1 hour, 1 day, 2 days, 7 days and 14 days after injection.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.8 - 1 mg/kg bw
- Based on:
- test mat.
- Mortality:
- After 14 days:
0/20 deaths at 0.25 mg/kg bw
6/20 deaths at 0.64 mg/kg bw
4/20 deaths at 0.8 mg/kg bw
12/20 deaths at 1 mg/kg bw
16/20 deaths at 1.25 mg/kg bw
19/20 deaths at 1.67 mg/kg bw
20/20 deaths at 4 and 32 mg/kg bw
At the highest dose first deaths were observed 1 hour after administration. Over the entire dose range first deaths occurred after about 48 hours. - Clinical signs:
- 0.25-1.6 mg/kg bw:
directly after injection: tremble, convulsions and uncoordinated movements, extension and retardation of extremities during movement, heavy breathing, avoidance of abdominal position and fallen-in flanks. The following days: abdominal posture, apathy, closed eyes with stuck together eyelids, apnea and bristly fur. Surviving animals showed no symptoms after 3-11 days.
4 and 32 mg/kg bw:
directly after injection: jumping and stagger, heavily accelarated breathing. After about 10 minutes: abdominal position, bushy fur, closed eyes and apathy. Continuation of symptoms untill death in the following days. - Gross pathology:
- Animals dying during the test: dark-blooded abdominal cavity, corosive lesions of gastrointestinal tract, slight abdominal adhesions, fatty liver (1 naimal) vessel-injected winding of small intestine.
Animals sacrificed after the observation period: adhesions in the liver area
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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