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EC number: 913-888-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Liquid form:
Oral absorption: In aqueous environments, such as the body the ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate is completely dissociated into the ammonium (NH4 +) and the phopshate (PO4 3-) ions. Phosphates are absorbed from the gastrointestinal tract as orthophosphate. The transport of phosphate from the lumen is an active, energy-dependent process, and there are factors that appear to modify the degree of its intestinal absorption. Vitamin D stimulates phosphate absorption, and this effect has been reported to precede the action of the vitamin on transport of calcium ion. In general, about two thirds of the ingested phosphate is absorbed from the gastrointestinal tract in adults. Absorbed phosphate is almost entirely excreted into the urine. After ingestion, ammonium ions can be absorbed by diffusion of the unionized ammonia or by active transport of ammonium ion. After intestinal absorption, ammonium ions are converted to urea by the liver, and subsequently excreted in urine. Based on low MW and high water solubility, high oral absorption is expected. Therefore, 100% absorption is taken for oral exposure.
Inhalation: Since the vapour pressure of the liquid form of the reaction mass of Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate is low (assimilated to the vapour pressure of water), inhalation exposure to the liquid form of the reaction mass is not expected.
Dermal exposure: Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate
ionize as soon as they dissolve and having water solubility above 10 g/L. Moreover, these substances may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Therefore, 10% dermal absorption of the reaction mass is proposed.
Solid form:
Oral absorption: In aqueous environments, such as the body the ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate is completely dissociated into the ammonium (NH4 +) and the phopshate (PO4 3-) ions. Phosphates are absorbed from the gastrointestinal tract as orthophosphate. The transport of phosphate from the lumen is an active, energy-dependent process, and there are factors that appear to modify the degree of its intestinal absorption. Vitamin D stimulates phosphate absorption, and this effect has been reported to precede the action of the vitamin on transport of calcium ion. In general, about two thirds of the ingested phosphate is absorbed from the gastrointestinal tract in adults. Absorbed phosphate is almost entirely excreted into the urine. After ingestion, ammonium ions can be absorbed by diffusion of the unionized ammonia or by active transport of ammonium ion. After intestinal absorption, ammonium ions are converted to urea by the liver, and subsequently excreted in urine. Based on low MW and high water solubility, high oral absorption is expected. Therefore, 100% absorption is taken for oral exposure.
Inhalation: Due to the aerodynamic diameter of the solid form of the reaction mass of Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate (D50 = 3.25 mm and no particle lesser than 100 µm - see section 4.5 of the IUCLID on the reaction mass solid form particle size distribution) it is not expected that this substance will reach the nasopharyncheal region or subsequently the tracheobronchial or pulmonary region. Therefore, based on the high aerodynamic diameter of the reaction mass, inhalation exposure is not expected for the solid form.
Dermal exposure: Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate ionize as soon as they dissolve and having water solubility above 10 g/L. Moreover, these substances may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Therefore, 10% dermal absorption of the reaction mass is proposed.
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