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Diss Factsheets
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EC number: 216-940-1 | CAS number: 1704-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Unspecified to 1986-08-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report without statement of guideline used for study or certification of following GLP; however, the methodology provided was equivalent to OECD 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Clinical observations were made before dose (0 days) and at 7 and 14 days instead of daily.
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-[2-(dimethylamino)ethoxy]ethanol
- EC Number:
- 216-940-1
- EC Name:
- 2-[2-(dimethylamino)ethoxy]ethanol
- Cas Number:
- 1704-62-7
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- 2-[2-(dimethylamino)ethoxy]ethan-1-ol
- Reference substance name:
- DMEE
- IUPAC Name:
- DMEE
- Details on test material:
- - Name of test material (as cited in study report): DMEE (Dimethylaminoethoxyethanol)
- Molecular formula: (CH3)2NCH2CH2OCH2CH2OH
- Substance type: Pure active substance
- Physical state: liquid (amber, non-viscous)
- Analytical purity: 97.6
- Stability under test conditions: Stable for years as both undiluted test material and diluted in water.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: between 2.0 and 3.0 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- % coverage: N/A
- Type of wrap if used: Vetrap Bandaging Tape wrapped over the impervious sheeting of the intact, clipped skin
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Excess fluid removed to diminish ingestion
- Time after start of exposure: 24 hrs - Duration of exposure:
- 24 hrs
- Doses:
- Males: 0.50, 1.00, 1.41, and 2.00 mL/kg (the last dose was inferred by reviewer from lower doses and LD50; first number is erased in study's table).
Females: 0.50, 1.00, 2.00 (this dose inferred by reviewer from other doses and LD50; first number is erased in study's table), and 4.00 mL/kg. - No. of animals per sex per dose:
- 5 males and 5 females were included on each level for the LD50 calculation.
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing at 0 days (before dose), 7 days and 14 days (just prior to sacrifice).
- Necropsy of survivors performed: yes - Statistics:
- Moving average method (Thompson, 1947 (reference in OECD 402); Weil, 1983).
Results and discussion
- Preliminary study:
- N/A
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.74 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 1.5 - 2.01
- Remarks on result:
- other: Using the density for DMEE of 0.95 g/mL to convert to mg/kg bw resulted in a LD50 value of 1663 mg/kg bw.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2.14 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 1.45 - 3.17
- Remarks on result:
- other: Using the density for DMEE of 0.95 g/mL to convert to mg/kg bw resulted in a LD50 value of 2033 mg/kg bw.
- Mortality:
- Time of death ranged from 1 to 4 days.
- Males: 4/5 of the 2.00 mL/kg group died, 0/5 of the 1.41 mL/kg group, 0/5 of the 1.00 mL/kg group, 0/5 of the 0.50 group.
- Females: 5/5 of the 4.00 mL/kg group, 2/5 of the 2.00 mL/kg group. - Clinical signs:
- other: Local dermal effects included: erythema, edema, necrosis, ecchymosis, fissuring, ulceration, desquamation and scabs. Dermal reactions persisted through 14 days. Salvation, sluggishness, unsteady gait, red discharge (from nose and mouth), tremors (in 2) an
- Gross pathology:
- Gross pathology findings included red and mottled lungs, red tracheas, a few discolored livers and kidneys, and subcutaneous edema.
- Other findings:
- N/A
Any other information on results incl. tables
The author of the study concluded that DMEE was moderately toxic following its administration by single dermal application. The criteria used for interpretation of results is listed above under "Any other information on materials and methods incl. tables".
Applicant's summary and conclusion
- Conclusions:
- The LD50 for percutaneous exposure to male rabbits was 1.74 mL/kg (1663 mg/kg bw) and to female rabbits was 2.14 mL/kg (2033 mg/kg bw). Severe skin irritation was apparent on each rabbit through death or sacrifice at 14 days.
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