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Diss Factsheets
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EC number: 219-775-3 | CAS number: 2528-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Heptanoyl chloride
- EC Number:
- 219-775-3
- EC Name:
- Heptanoyl chloride
- Cas Number:
- 2528-61-2
- Molecular formula:
- C7H13ClO
- IUPAC Name:
- heptanoyl chloride
- Details on test material:
- Name of the test substance used in the study report: n-Heptansaeurechlorid
Degree of purity/content: 98.6 g/100 g (GC)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult rats were used for this experiment with a comparable body weight at the start of the study of 150 - 300 g. The animals were identifed using cage cards and group identification by tail marking. They were housed in fully air-conditioned rooms with central air-conditioning in a range of 20-24°C for room temperature and a relative humidity of 30-70%. The day/night rhythm was 12 hours dark and 12 hours light. Stainless steel wire mesh cages (type DK-III) were used (singly housing). A standardized animal diet and drinking water were available ad libitum. The acclimatization period was at least 1 week. The animals were given no feed at least 16 hours before administration (water was available).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- The test substance is sensitive to hydrolysis; good solubility in olive oil DAB 10.
- Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 15 days (200 mg/kg) resp. 14 days (2000 mg/kg)
Individual body weights were reported shortly before administration, thereafter weekly and at the end of the study.
Recording of signs and symptoms were done several times on the day of administration, at least once each workday for the individual animals.
A check for any dead or moribund animal was made twice each working day and once on weekends or on public holidays.
Necropsy on the last day of the observation period with withdrawal of food at least 16 hours before killig with CO2; then necropsy of all animals that died as soon as possible.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Impaired and poor general state, dyspnoea, apathy, abdominal position (only females), staggering, ataxia, atonia (only females), paresis (only females), tremor (only males), cyanosis (only males), piloerection, salivation (only males), compulsary gnawing
- Gross pathology:
- No pathological findings noted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.