Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-868-0 | CAS number: 7772-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 30 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- only oral study available
- AF for dose response relationship:
- 1
- Justification:
- correction via route, factor 1
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA REACH Guidance; subchronic - chronic: 2
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, Differences in species addressed in calculation of dose descriptor starting point
- AF for other interspecies differences:
- 5
- Justification:
- ECHA REACH Guidance, worker: 5
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.01 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 30.427 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- value form long term systems inhaltion without time scaling
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, Differences in species addressed in calculation of dose descriptor starting point
- AF for other interspecies differences:
- 5
- Justification:
- ECHA REACH Guidance, worker: 5
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance, worker: 1
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance
Local effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 12 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: German MAK Value; see assessment report in attachment
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: German MAK Value; see assessment report in attachment
- AF for dose response relationship:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for differences in duration of exposure:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for other interspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for intraspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for the quality of the whole database:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for remaining uncertainties:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.84 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: German MAK Value; see assessment report in attachment
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: German MAK Value; see assessment report in attachment
- AF for dose response relationship:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for other interspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for intraspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for the quality of the whole database:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for remaining uncertainties:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.34 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 34 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- ECHA REACH Guidance, only oral values available
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4,
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA REACH Guidance; subchronic - chronic: 2
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, only relevant for inhalation
- AF for other interspecies differences:
- 5
- Justification:
- ECHA REACH Guidance, worker: 5
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance,
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance,
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.69 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- ECHA REACH Guidance, only oral values available
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, only relevant for inhalation
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for intraspecies differences:
- 5
- Justification:
- ECHA REACH Guidance, worker: 5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance,
- AF for remaining uncertainties:
- 2
- Justification:
- factor for exposure tine, see justification
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.256 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 30.427 ng/m³
- Explanation for the modification of the dose descriptor starting point:
- only oral study available
- AF for dose response relationship:
- 1
- Justification:
- correction via route, factor 1
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA REACH Guidance; subchronic - chronic: 2
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, Differences in species addressed in calculation of dose descriptor starting point
- AF for other interspecies differences:
- 1
- Justification:
- correction via route, factor 1
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 30.427 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- no inhalation data available, starting point oral subchronic 2.28mg SnSO4 kg bw /day, f(oral-inhalation) 1/0.38
- AF for dose response relationship:
- 1
- Justification:
- ECHA REACH Guidance; rat-human: 4
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, Differences in species addressed in calculation of dose descriptor starting point
- AF for other interspecies differences:
- 10
- Justification:
- ECHA REACH Guidance, default value: 10
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance, default value: 1
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance
Local effects
Long term exposure
- Hazard assessment conclusion:
- other toxicological threshold
- Value:
- 2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: German MAK Value; see assessment report in attachment
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: German MAK Value; see assessment report in attachment
- AF for dose response relationship:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for differences in duration of exposure:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for other interspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for intraspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for the quality of the whole database:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for remaining uncertainties:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: German MAK Value; see assessment report in attachment
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: German MAK Value; see assessment report in attachment
- AF for dose response relationship:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for other interspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for intraspecies differences:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for the quality of the whole database:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
- AF for remaining uncertainties:
- 1
- Justification:
- German MAK Value; see assessment report in attachment
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.172 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 34.51 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- ECHA REACH Guidance, only oral values available
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4,
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA REACH Guidance, subchronic - chronic 2
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, only relevant for inhalation
- AF for other interspecies differences:
- 10
- Justification:
- ECHA REACH Guidance, general population: 10
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- , default value: 2.5 ECHA REACH Guidance,
- AF for remaining uncertainties:
- 1
- Justification:
- , default value: 2.5 ECHA REACH Guidance,
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.35 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 34.51 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- ECHA REACH Guidance, only oral values available
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4,
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, only relevant for inhalation
- AF for other interspecies differences:
- 10
- Justification:
- ECHA REACH Guidance, general population: 10
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance, 1
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance, 1
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.172 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 34.51 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not relevant, oral data
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4,
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA REACH Guidance, subchronic - chronic 2
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, only relevant for inhalation
- AF for other interspecies differences:
- 10
- Justification:
- ECHA REACH Guidance, general population: 10
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance,
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA REACH Guidance,
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 34.51 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 6.6
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2.11 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not relevant, oral data
- AF for dose response relationship:
- 4
- Justification:
- ECHA REACH Guidance; rat-human: 4,
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA REACH Guidance, only relevant for inhalation
- AF for other interspecies differences:
- 10
- Justification:
- ECHA REACH Guidance, general population: 10
- AF for intraspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance,, default value: 2.5
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA REACH Guidance,: efault = 1
- AF for remaining uncertainties:
- 12
- Justification:
- ECHA REACH Guidance,: efault = 1
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.