Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- DuPont Co. (1996). Haskell Laboratory Report No. 1028-96 (unpublished);|cited in DuPont Co. (2001). Robust summary for 1,5,9-cyclododecatriene. Submitted to U.S. EPA on 11 Dec. 2001. Also cited in TSCA fiche OTS0558489-1
- Reference Type:
- publication
- Title:
- Robust summary for 1,5,9-cyclododecatriene (revised).
- Author:
- DuPont Safety, Health & Environmental Excellence Center, Wilmington (Del., USA)
- Year:
- 2 003
- Bibliographic source:
- U.S. EPA, 46 pp
- Reference Type:
- publication
- Title:
- Support: Letter from DuPont Chem to USEPA re: Neurotoxicity inhalation toxicity study and a micronucleus inhalation study in rats with 1,5,9-cyclododecatriene,
- Author:
- DuPont Chem. (1996). Support: Letter from DuPont Chem to USEPA re:
- Year:
- 1 996
- Bibliographic source:
- NTIS/OTS Microfiche 0558489-1, Doc 89-960000191, dated 07/29/96.
Materials and methods
- Principles of method if other than guideline:
- Method: other: see references
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 1,5,9-cyclododecatriene
- IUPAC Name:
- 1,5,9-cyclododecatriene
- Details on test material:
- TS: 1,5,9-cyclododecatriene, purity 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD) BR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Age: 51 days
- Weight at study initiation: mean 231.4 g
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- air
- Details on exposure:
- ADMINISTRATION: nose-only
- vapour atmosphere generated by metering the liquid test substance into a nebulizer
Sampling times and number of samples:
- Test atmosphere: one sample during each exposure to determine concentration and particle size distribution; result: 3200 +/- 280 mg/m3; mass median aerodynamic diameter 3.6 µm
-atmospheric concentration measured by gas chromatography and gravimetric analysis
-further details: see references
- Duration of treatment / exposure:
- 6 hours each on 2 consecutive days
- Frequency of treatment:
- once per day on 2 consecutive days
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
500 ppm = 3300 mg/m3 (aerosol/vapor)
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
3200 (+/- 280) mg/m3 (aerosol/vapour)
Basis:
analytical conc.
- No. of animals per sex per dose:
- No. of animals per dose: 10 exposed, 5 negative control
- Control animals:
- yes
- Positive control(s):
- Control groups and treatment:
- positive: 40 mg cyclophosphamide/kg by oral intubation
-negative: concurrent houseline air
Examinations
- Tissues and cell types examined:
- Bone marrow: At least 3 slides per rat (fixed, and stained with acridine orange), 2000 PCEs per rat scored for micronuclei, 1000 erythrocytes scored for PCE/NCE ratio ; Representative slides from each rat were examined blindly.
further EXAMINATIONS:
- Clinical observations: during exposure (including alerting stimulus)
- Organs examined at necropsy: marrow from 1 femur
- Body weights: yes
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Remarks:
- no mortalities
- Additional information on results:
- MORTALITY: no test substance-induced mortality
CLINICAL SIGNS:
- During exposure: no clinical signs, response to alerting stimulus diminished or absent
- After exposure: lethargy and/or irregular respiration.
BODY WEIGHT CHANGES: losses in treated and positive control rats
EFFECT ON MITOTIC INDEX OR PCE/NCE RATIO: No statistically significant depressions in the proportion of PCEs among 1000 erythrocytes were observed.
GENOTOXIC EFFECTS: There were no statistically significant increases in the MNPCE frequency in rats exposed to the test substance. A statistically significant increase in the MNPCE frequency was found in the positive control rats.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.