Reaction mass of 6-O-alfa-D-glucopyranosyl-D-fructofuranose and 1-O-alfa-D-glucopyranosyl-D-fructofuranoseand D-fructofuranose

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other:

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Review paper that summarizes the metabolism of isomaltulose, the main component of isomaltulose greens along with trehalulose.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2002

Materials and methods

Objective of study:

metabolism

Principles of method if other than guideline:

The study reviewed the metabolism of isomaltulose as documented in other studies.

GLP compliance:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

Isomaltulose is a structural isomer of sucrose and the main component of isomaltulose greens along with another isomer, trehalulose.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no bioaccumulation potential based on study results

Executive summary:

Isomaltulose, a main component of isomaltulose greens and a structural isomer of sucrose, is hydrolyzed slowly in the intestinal tracts of mammals, though metabolism may be more rapid in rats and dogs than humans. In humans, isomaltulose is largely and rapidly excreted in the urine unchanged. The other main component of isomaltulose greens, trehalulose, is also a structural isomer of sucrose and thus would have the same metabolic characteristics as isomaltulose.