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EC number: 426-790-0 | CAS number: 162208-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V Method (B1.bis)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
- EC Number:
- 426-790-0
- EC Name:
- Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
- Cas Number:
- 162208-27-7
- Molecular formula:
- Hill formula: C10 H16 N3 O5 P S2
- IUPAC Name:
- diethoxy(sulfanylidene)-lambda5-phosphanyl (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetate
Constituent 1
Test animals
- Species:
- other: Rat (Sprague-Dawley origin)
Administration / exposure
- Vehicle:
- other: Corn oil.
- No. of animals per sex per dose:
- Preliminary sighting study: 2 (female)
Main study: 10 (male)
Main study: 10 (female) - Details on study design:
- Preliminary sighting study:
A preliminary sighting study was carried out by dosing
female rats at 500 and 2000 mg/kg bodyweight.
Main study:
A group of ten rats (five male and five female) were dosed
at 500 mg/kg bodyweight. A further group of ten rats (five
males and five females) was dosed at 50 mg/kg bodyweight.
Results and discussion
- Preliminary study:
- Species/strain: Rats (Sprague-Dawley origin)
2000 mg/kg bw: Evident toxicity: Y; Mortality: Y
500 mg/kg bw: Evident toxicity: Y; Mortality: N
Observations:
Initially one animal was dosed at 500 mg/kg bodyweight.
Clinical signs in this animal comprised piloerection,
hunched posture, waddling/unsteady gait, increased
respiration, soft to liquid yellow/brown discoloured faeces,
increased/clear urine and ungroomed appearance (ano/genital
region). Recovery was complete by Day 8. Bodyweight gain was
considered satisfactory and the animal was sacrificed on Day
8. No macroscopic abnormalities were observed at post mortem
examination.
A further female was treated at 2000 mg/kg bodyweight.
Clinical signs noted in this animal prior to death comprised
of piloerection only. This animal died within one hour of
dosing. Macroscopic examination of this animal revealed
congestion (characterised by dark appearance) of the liver
and spleen. Fluid contents were noted in the stomach.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 50 mg/kg bw
- Dose descriptor:
- other: 500 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: 5; No. of deaths: 5; No. of animals used: 5
- Dose descriptor:
- other: 50 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: 5; No. of deaths: 0; No. of animals used: 5
- Dose descriptor:
- other: 500 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: 5; No. of deaths: 4; No. of animals used: 5
- Clinical signs:
- Signs of toxicity:
Five males and four females dosed at 500 mg/Kg bodyweight
died within 3 hours of dosing. Piloerection was observed in
all rats within six minutes of dosing and was accompanied in
rats later on Day 1 and/or at later intervals during the
study by:
Hunched posture and abnormal faeces, seen in all animals at
50 and 500 mg/kg;
Waddling/unsteady gait, lethargy, abnormal respiration and
pallid extremities in all males and one female at 500 mg/kg;
Partially closed eyelids and increased lacrimation in one
male and one female at 500 mg/kg;
Walking on toes in all rats at 500 mg/kg;
Discoloured urine, body tremors and blue/cold extremities in
one female at 500 mg/kg;
Ungroomed appearance in all rats at 500 mg/kg and one male
and one female at 50 mg/kg.
Recovery of the surviving female treated at 500 mg/kg was
complete by Day 9. For rats treated at 50 mg/kg, all signs
with the exception of piloerection had resolved by Day 2.
Recovery of all rats treated at 50 mg/kg was complete by Day
5. - Gross pathology:
- Effects on organs:
Macroscopic examination of the nine animals which died
within three hours of dosing revealed congestion of the
subcutaneous tissue, brain, heart, lungs, liver, kidneys,
stomach and alimentary tract. Pallor was noted in the
subcutaneous tissue, brain, stomach and small intestine.
Enlargement of the heart and stomach were also noted.
Congestion with fluid contents and gaseous distension were
also noted in the stomach and alimentary tract.
Macroscopic examination of the one surviving female treated
at 500 mg/kg and all rats at 50 mg/kg, killed at Day 15
revealed no abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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