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EC number: 204-111-7 | CAS number: 115-84-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 April 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-butyl-2-ethylpropanediol
- EC Number:
- 204-111-7
- EC Name:
- 2-butyl-2-ethylpropanediol
- Cas Number:
- 115-84-4
- Molecular formula:
- C9H20O2
- IUPAC Name:
- 2-butyl-2-ethylpropane-1,3-diol
- Reference substance name:
- 2-Butyl-2-ethyl-1,3-propanediol (BEPD)
- IUPAC Name:
- 2-Butyl-2-ethyl-1,3-propanediol (BEPD)
- Details on test material:
- - Name of test material (as cited in study report): BEPD and BEDP
- Physical state: white solid
- Analytical purity: >99%
- Water solubility: 8 g/L at 20°C
- Volatility: <2.0 Pa at 20°C
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Sampling and analysis
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Obtained from Louddens municipal sewage plant, Stockholm, Sweden and sampled on April 8, 1998. The sludge contained 20 g dry matter/L after prescribed washing and centrifugation.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- Not applicable
Test conditions
- Hardness:
- Not applicable
- Test temperature:
- Not reported
- pH:
- Not applicable
- Dissolved oxygen:
- Not reported
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- concentration of BEPD used: 0 , 51.5, 103, 258, 515 and 2575 mg/L, calcuated from total organic carbon (TOC).
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 650 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- 2 600 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- 3,5-dichlorophenol was tested at 1, 5, 10 and 25 mg/L. Inhibition of respiration compared to the control after 3 hours was 27, 45, 62 and 86% at 1, 5, 10 and 25 mg/L.
- Reported statistics and error estimates:
- 3 hour EC50 was determined from a plot (log normal).
Any other information on results incl. tables
Results of the definitive test
BEPD (mg/L) calculated from TOC |
Inhibition of respiration related to control (%) 30 mins |
Inhibition of respiration related to control (%) 3 hours |
Reference 3,5-dichlorophenol (mg/L) |
Inhibition of respiration related to control (%) 3 hours |
||
0 |
0 |
0 |
0 |
0 |
0 |
0 |
51.5 (1%) |
19 |
22 |
21 |
22 |
1 |
27 |
103 (2%) |
25 |
28 |
26 |
28 |
5 |
45 |
258 (5%) |
42 |
44 |
42 |
35 |
10 |
62 |
515 (10%) |
42 |
48 |
46 |
49 |
25 |
86 |
2575 (25%) |
79 |
76 |
80 |
82 |
|
|
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The EC50 for the reference inhibitor, 3,5-dichlorophenol was in the range of 5 - 30 mg/L.
- Conclusions:
- The 3-hour EC50 of BEPD based on suppression of the respiration of activated sludge microorganisms was 650 mg/L.
- Executive summary:
Activated sludge obtained from a sewage treatment plant was exposed in a 3 -hour respiration inhibition test to concentrations of 0, 51.1, 103, 258, 515 and 2575 mg BEPD/L, nominal concentrations were calculated from TOC. The test design included duplicate samples and followed OECD 209 guidelines. The 3 -hour EC50 based on respiration inhibition was 650 mg BEPD/L.
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