Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-175-6 | CAS number: 1762-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Thiocyanates are not genotoxic, and although thiocyanate is able to induce hyperplasia (goitre), it is not known whether humans are susceptible, as are rodents, to the development of thyroid cancer from thyroid-pituitary disruption.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Link to relevant study records
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Very limited reporting. Single dose level. The study was not performed according to OECD guidline or under GLP.
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Frederik cancer research facility
- Age at study initiation: 8 weeks
- Weight at study initiation: no data
- Fasting period before study: not applicable
- Housing: 4 to a cage
- Diet (e.g. ad libitum): Purine Autoclavable Laboratory chow, ad libitum.
- Water (e.g. ad libitum): each cage of rats was given 80 ml of a solution of sodium thiocyanate or of sodium nitrite + sodium thiocyante each day for 5 days of each week. On the remaining 2 days the rats were given acidified (to ph 2.5) tap water ad libitum to allow them to make up any water definciency they had incurred.
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data - Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
no data - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- The life span of the rats, over 2 years.
- Frequency of treatment:
- Each cage of rats was given 80 ml of a solution of sodium thiocyanate or of sodium nitrite + sodium thiocyante each day for 5 days of each week. On the remaining 2 days the rats were given acidified (to ph 2.5) tap water ad libitum to allow them to make up any water definciency they had incurred.
- Post exposure period:
- No post exposure period.
- Remarks:
- Doses / Concentrations:
0.32%
Basis:
nominal in water
approximately 250 mg/kg bw - No. of animals per sex per dose:
- 20
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: based on earlier experiments
- Rationale for animal assignment (if not random): no data
- Rationale for selecting satellite groups: not applicable
- Post-exposure recovery period in satellite groups: not applicable
- Section schedule rationale (if not random): no data - Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- All of the treated animals were allowed to die naturally, or killed when moribund, expet for survivors which were sacrificed at week 130. Each animals was necropsied, all lesions and major organs and tissues were fixed in formalin, embedded in papaffin, sectioned and stained with hematoxylin and eosin for histologic examination.
- Other examinations:
- None
- Statistics:
- No data
- Relevance of carcinogenic effects / potential:
- Due to the limitations of the study, no conclusion on the carcinogenic activity and/or promotor activity of the thiocyanate can be drawn.
- Conclusions:
- Treatment with sodium thiocyante did not affect the treated rats noticably, mortality was not increased. There is no indication in the results of this study that sodium thiocyanate, alone or mixed with sodium nitrite is carcinogenic. However due to the limitations of the study, no conclusion on the carcinogenic activity and/or promotor activity of the thiocyanate can be drawn.
- Executive summary:
Chronic toxicity tests of sodium thiocyanate with sodium nitrite in F344 rats. Lijinsky W, Kovatch RM Toxicol Ind Health 1989 Jan 5:1 25-9.
Abstract: Sodium thiocyanate, a common environmental chemical, was found to increase the incidence of liver tumors in a group of rats treated with 0.08% in drinking water. To test the possibility that thiocyanate was catalyzing the formation of carcinogenic nitrosamines from amines and nitrite in the food, a group of 20 male and 20 female rats was given a higher dose of sodium thiocyanate (0.32%) together with sodium nitrite (0.2%) in drinking water. Similar groups of rats were given 0.32% sodium thiocyanate or 0.2% sodium nitrite in drinking water or were untreated. All treatments lasted most of the lifetime of the rats, at least 2 years. There was no difference between the groups, treated or untreated, in survival, or in the incidence of any tumor that could be related to the treatment. The results indicate that sodium thiocyanate is without carcinogenic activity in rats, alone or combined with sodium nitrite.
Reference
Treatment with sodium thiocyante did not affect the treated rats noticably, mortality was not increased. There is no indication in the results of this study that sodium thiocyanate, alone or mixed with sodium nitrite is carcinogenic.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- Due to the limitations of the study, no conclusion on the carcinogenic activity and/or promotor activity of the thiocyanate can be drawn.
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Thiocyanates are not genotoxic, and although thiocyanate is able to induce hyperplasia (goitre), it is not known whether humans are susceptible, as are rodents, to the development of thyroid cancer from thyroid-pituitary disruption. Available data is not sufficient to justify classification.
Additional information
A chronic study (Lijinsky W, Kovatch RM Toxicol Ind Health 1989 Jan 5:1 25-9) in rats supplied with 0.32% thiocyanate together with sodium nitrite (0.2%) in their drinking water for at least for 2 years, showed no effects in survival, or in the incidence of any tumor that could be related to the treatment. Due to limited reporting, a low validity was assigned to this report.
Thiocyanates are naturally occurring substances with ubiquitous presence in living nature. Many studies evaluated the background thiocyanate levels in serum of man showing levels between 23 to 50 µmol/L to up to 100 µmol/L in case of smokers.Tsuge (2000) reported background serum concentrations of thiocyanate of 33.5 ± 25.4 µM for non-smokers and 111.2 ± 92.1 µM smokers, and after diner levels up to 160 µM (equivalent to 12 mg NH4SCN/L!) in serum were seen (Eminedoki, 1994).Thiocyanates are not genotoxic, and although thiocyanate is able to induce hyperplasia (goitre), it is not known whether humans are susceptible, as are rodents, to the development of thyroid cancer from thyroid-pituitary disruption. In any case, it appears that humans are less sensitive to the carcinogenic effects than are rodents. Therefore, a further carcinogenicity study in rodents is not justified.
Justification for selection of carcinogenicity via oral route endpoint:
Only carcinogenicity study identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.