Registration Dossier
Registration Dossier
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EC number: 203-685-6 | CAS number: 109-59-1
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 1, 2001 - March 27, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Test according to guideline. The test report from the Chemicals Evaluation and Research Institute of Japanis not available, but all the data were validated by the Japanese authorities within the OECD SIDS program Information in this record is from therefore from the SIDS dossier, a reliable secondary source, and used as supportive information.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 009
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 28, 2-(1-methylethoxy)ethanol
- Author:
- OECD
- Year:
- 2 009
- Bibliographic source:
- http://cs3-hq.oecd.org/scripts/hpv/index.asp
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-isopropoxyethanol
- EC Number:
- 203-685-6
- EC Name:
- 2-isopropoxyethanol
- Cas Number:
- 109-59-1
- Molecular formula:
- C5H12O2
- IUPAC Name:
- Propan-2-ol
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
Duration of test
- Duration:
- 5 d
- Temp.:
- 50
- Initial conc. measured:
- ca. 200 mg/L
Results and discussion
- Transformation products:
- no
Total recovery of test substance (in %)open allclose all
- % Recovery:
- > 98.4 - < 102
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- > 96.4 - < 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- > 102 - < 103
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
Dissipation DT50 of parent compound
- Remarks on result:
- hydrolytically stable based on preliminary test
Any other information on results incl. tables
Residue after 5 days
pH 4: 102 %, 98.4 %
pH 7: 100 %, 96.4 %
pH 9: 103 %, 102 %
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No hydrolysis was observed at pHs 4, 7 and 9 for 5 days at 50 degree C.
- Executive summary:
2 -isopropoxyethanol is stable in water as hydrolysis test according to guideline showed nno hydrolysis at pH 4, pH 7 and pH 9 at 50 degree C for 5 days.
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