Registration Dossier
Registration Dossier
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EC number: 218-644-8 | CAS number: 2210-74-4
Endpoint summary
Administrative data
Description of key information
The acute dermal toxicity in rat was performed following the OECD guidelines no.402 (Acute Dermal Toxicity" (adopted 24 February 1987) and the Method B.3 Acute Toxicity (Dermal) of Commission Regulation (EC) no.440/2008.
The acute oral toxicity in rat - fixed dose method was performed following the OECD guidelines no.420 (Acute Oral Toxicity - Fixed Dose Method" (adopted 17 December 2001) and the Method B.1 bis Acute Toxicity (Oral) of Commission Regulation (EC) no.440/2008.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: November 2011
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: 10 June 2013
Additional information
The acute dermal median lethal dose (LD50) of the test item in the Wistar rat was found to be greater than 2000 mg/kg bw.
The acute oral median lethal dose (LD50) of the test item in the female Wistar rat was estimated to be greater than 2000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Experimental study from Supplier.
Justification for selection of acute toxicity – dermal endpoint
Experimental study from Supplier.
Justification for classification or non-classification
On the base of the reported results for the acute oral and dermal toxicity studies, the test item does not required classification for these hazard.
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