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EC number: 203-137-6 | CAS number: 103-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- CYP oxidative metabolism contributes to the potency of phenylisocyanate
- Author:
- Chadda GP, Lange RW, Korzekwa K, Romkes M, Day BW, Karol MH
- Year:
- 1 998
- Bibliographic source:
- The Toxicologist
Materials and methods
- Principles of method if other than guideline:
- Cell-mediated immunity (CMI) responses were examined in Balb/c mice after sensistisation.
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test material
- Reference substance name:
- Phenyl isocyanate
- EC Number:
- 203-137-6
- EC Name:
- Phenyl isocyanate
- Cas Number:
- 103-71-9
- Molecular formula:
- C7H5NO
- IUPAC Name:
- isocyanatobenzene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Duration of treatment / exposure:
- see examinations
- Frequency of treatment:
- see examinations
- Post exposure period:
- see examinations
- No. of animals per sex per dose:
- no data
Results and discussion
- Details on results:
- Antibody titers, measured by ELIDS were reduced > 50% in ABT pretreated animals. ABT administered alone had no effect on either CMI or HI. These results suggest that oxidative metabolism of aromatic isocyanates, creating a bifunctional hapten, enhances the sensitisation potency of these chemicals
Any other information on results incl. tables
Antibody titers, measured by ELIDS were reduced > 50% in ABT pretreated animals. ABT administered alone had no effect on either CMI or HI. These results suggest that oxidative metabolism of aromatic isocyanates, creating a bifunctional hapten, enhances the sensitisation potency of these chemicals
Applicant's summary and conclusion
- Executive summary:
Balb/c mice were sensitised by subcutaneous injection of 30 µmol PI (day 0) inthe presence and absence of molar equivalents of the CYP suicide inhi9bitor 1 -aminobenzothiazole (ABT). ABT was administered at 0.25 and 2 hr prior to sensitisation. Cell-mediated immunity (CMI) responses were elicited by challenge at the dorsal sufrace of the ear (day 4) with 0.67 µmoles PI. ear thickness measurements were obtained 48 hr later (day 6). CMI was significantly reduced (> 20%) by ABT pretreatemnt. Effects on humoral immunity (HI) were assessed in a separate group of animals where PI sensitisation was performed with or without ABT pretreatment. After 14 days, sera were obtained for evaluation of PI-specific IgG.
Antibody titers, measured by ELIDS were reduced > 50% in ABT pretreated animals. ABT administered alone had no effect. on either CMI or HI. These results suggest that oxidative metabolism of aromatic isocyanates, creating a bifunctional hapten, enhances the sensitisation potency of these chemicals.
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