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Diss Factsheets
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EC number: 201-199-9 | CAS number: 79-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No GLP and no guideline was followed. Only the liver was examined for effects.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- The Wist 30 young rats (from Biobaza IISP, Cluj-Napoca, Romania), of both sexes, weighing 70-150 g, divided into 3 groupswere used. Control group, consisting 10 rats (5 males and 5 females) and tested groups consisting 10 rats (5 males and 5 females). One tested group was treated with 1% DL50 concentration dichloroacetyl chloride and the other with 5% DL50 concentration dichloroacetyl chloride. active. Dose was administrated at the beginning of the experiment and then twice a week. The conditions of care, feeding and administration were the same in' all the groups.The animals were monitored to fully consume the mixture received. On the 28th day of experiment animals were killed after deep anesthesia with ether and then, after laparotomy, the liver was harvested from which we sampled fragments for histological processing.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dichloroacetyl chloride
- EC Number:
- 201-199-9
- EC Name:
- Dichloroacetyl chloride
- Cas Number:
- 79-36-7
- Molecular formula:
- C2HCl3O
- IUPAC Name:
- 2,2-dichloroacetyl chloride
- Details on test material:
- - Name of test material (as cited in study report): dichloroacetyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 70-150g
Administration / exposure
- Route of administration:
- other: oral with milk
- Vehicle:
- other: sunflower oil
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1 % of LD50/d
Basis:
no data
- Remarks:
- Doses / Concentrations:
5%of LD50/d
Basis:
no data
- No. of animals per sex per dose:
- 5 per sex
- Control animals:
- yes
Results and discussion
Results of examinations
- Details on results:
- In kidney and liver, no compound-related histopathological changes were evident
Kidney as well as liver: no substance-related histopathological effects were observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Dichloroacetyl chloride does not show any toxic effect on the liver as far as the above concentrations and methodology are concerned.
- Executive summary:
The Wist 30 young rats (from Biobaza IISP, Cluj-Napoca, Romania), of both sexes, weighing 70-150 g, divided into 3 groupswere used. Control group, consisting 10 rats (5 males and 5 females) and tested groups consisting 10 rats (5 males and 5 females). One tested group was treated with 1% DL50 concentration dichloroacetyl chloride and the other with 5% DL50 concentration dichloroacetyl chloride (dose repeated twice per week).
In conclusion, dichloroacetyl chloride does not show any toxic effect on the liver as far as the above concentrations and methodology are concerned.
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