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EC number: 204-436-4 | CAS number: 120-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Since no toxicokinetic studies are available for 2-imidazolidone the following assessment is based on the available physicochemical properties and results from other toxicological studies.
The substance is a white/yellowish solid with faint specific odour and with a molecular weight of 86.0925 g/mol. The calculated log Pow value is -1.16 at 25 °C and the calculated solubility in water is 596 g/L at 20°C. High water solubility and low molecular weight (< 200 g/mol) suggest that the substance may readily dissolve into the gastrointestinal fluids. In case of low molecular weight substances (MW < 200 g/mol) the substance may also pass through aqueous pores or be carried through the epithelial barrier by the bulk passage of water. It is thus expected that the substance will be readily absorbed by gastrointestinal tract.
No experimental data is available concerning the respiratory hazard of 2-imidazolidone. Generally, water-soluble dusts would readily diffuse/dissolve into the mucus lining of the respiratory tract. Very hydrophilic substances may be absorbed through aqueous pores (for substances with molecular weights below around 200 g/mol) or be retained in the mucus and transported out of the respiratory tract. Overall it is therefore expected that the substance will be readily absorbed by inhalation.
According to Chapter R.8 of REACH Guidance on information requirements and chemical safety assessment, it is proposed in the absence of route-specific information on the starting route, to include a default factor of 2 in the case of oral-to-inhalation extrapolation. This approach will be taken forward to DNEL derivation.
The low log Pow (< -1) value and the high water solubility (> 10000 mg/L) suggest that the substance may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Dermal uptake for these substances will be very low. This is supported by the estimated Kp value of 0.000167 cm/h using the Danish (Q)SAR Database (EPI Suite, DERMWIN V 2.01) indicative for a very low dermal penetration potential according to DK-EPA heuristics (User Manual for the Internet Version of the Danish (Q)SAR Database, Database Version 1, May 2005). In the available acute dermal study no effects were observed (Bioassay, 2012). In the absence of route-specific information and based on the available information a ratio of 0.1 for oral to dermal absorption is provisionally suggested for the risk assessment of the substance, based on its physico-chemical properties and (Q)SAR estimation.
In the key studies concerning repeated dose toxicity (BASF, 88R0054/08C017, 2013; BASF, 50C0054/08S034, 2018), target organ was the thyroid gland. The results of these studies provide evidence concerning distribution of the substance or metabolites thereof.
The results from several in vitro genotoxity studies with and without metabolic activation suggest that no genotoxic metabolite was formed after the addition of rat liver S9 mix. Furthermore, the results of an in vitro study indicate that under physiological conditions reactive metabolites from 2-imidazolidone generated by either flavin-containing monooxygenase (FMO) or cytochrom P-450 are preferentially trapped by endogenous GSH and do not interact with cellular targets (Decker et al., 1991).
No studies are available for the bioaccumulation assessment of the substance. However, based on the low log Pow of -1.18 accumulation of the substance in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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