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EC number: 219-847-4 | CAS number: 2550-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The short-term toxicity of the substance 4-phenylbutan-2-one to aquatic invertebrates was studied in a limit test in accordance with OECD TG 202. No effects were seen at a nominal test concentration of 100 mg/L (95.4 mg/L as determined by TOC analysis). Studies on the short-term toxicity of the substance to fish and algae are not available. These endpoints were covered by studies with the structurally similar substance acetophenone, for which valid and reliable studies in accordance with official testing guidelines are available. The study of acute toxicity of acetophenone to fish (Pimephales promelas) over a period of 96 hours under flow-through conditions resulted in a LC50 value of 162 mg/L (converted to 199.8 mg/L for 4-phenylbutan-2-one). The study of acute algal toxicity of acetophenone was conducted under static conditions over a period of 72 hours with Pseudokirchneriella subcapitata. The EC50 and NOEC values based on the inhibition of growth rate were 86.4 mg/L and 24.8 mg/L (converted to 106.6 mg/L and 30.6 mg/L for 4-phenylbutan-2-one). It appears from the available data on aquatic short-term toxicity of the substance and structurally similar substances that freshwater algae are most sensitive to acute exposure to 4-phenylbutan-2-one or to the structurally related substance acetophenone. Since studies on the long-term aquatic toxicity of the substance are not available, the PNEC values will be derived from the converted EC50 value based on algal growth rate of 106.6 mg/L by applying appropriate assessment factors.
No microbial toxicity of 4-phenylbutan-2-one was seen in a toxicity control conducted in the course of the study on the ready biodegradability of the substance at a nominal concentration of 5 mg/L. The substance was readily biodegradable at this test concentration. Further testing of the inhibition of activated sludge respiration is therefore not necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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