Registration Dossier
Registration Dossier
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EC number: 238-056-5 | CAS number: 14205-39-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Single administration of seven concentrations with an application volume of 20 ml/kg to fasted rats (5 males and 5 females) via stomach tube with an observation period of 14 days
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity, rat
- Limit test:
- no
Test material
- Reference substance name:
- Methyl 3-aminocrotonate
- EC Number:
- 238-056-5
- EC Name:
- Methyl 3-aminocrotonate
- Cas Number:
- 14205-39-1
- Molecular formula:
- C5 H9 O2 N
- IUPAC Name:
- methyl 3-aminocrotonate
- Details on test material:
- 3-Aminocrotonsäuremethylester, solid, content and identity not certified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol (PEG 400)
- Doses:
- 1.3, 1.5, 1.8, 1.9, 2.0, 2.5 and 3.1 g/kg with an application volume of 20 ml/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 760 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 610 - 1 910
Any other information on results incl. tables
No symptoms in males and females at doses of 1.3 g/kg
Symptoms at doses of 1.5 g/kg and above: reduced general condition, cyanosis, ventral or lateral position, narcosis, dyspnea
Onset / Duration of symptoms: clinical signs occurred after 5 to 10 min after administration, on day 3 all (surviving) animals were free of symptoms
All death occurred on the first day after administration
Dissection of dead animals: bleedings in the mucous membrane of the stomach
No abnormal findings were seen at final necropsy
Applicant's summary and conclusion
- Executive summary:
The acute oral toxicity of methyl 3 -aminocrotonate was determined in fasted male and female rats after single administration of seven concentrations with an application volume of 20 ml/kg via stomach tube with an observation period of 14 d.
The acute oral LD50was 1760 mg/kg.
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