Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-290-4 | CAS number: 2702-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Mar 1992 - Jun 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Study type:
- biological exposure monitoring
- Endpoint addressed:
- genetic toxicity
- Principles of method if other than guideline:
- cytogenetic analysis of sister chromatid exchanges in lymphocytes obtained from exposed workers.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium 2,4-dichlorophenoxyacetate
- EC Number:
- 220-290-4
- EC Name:
- Sodium 2,4-dichlorophenoxyacetate
- Cas Number:
- 2702-72-9
- Molecular formula:
- C8H6Cl2O3.Na
- IUPAC Name:
- sodium 2-(2,4-dichlorophenoxy)acetate
- Details on test material:
- - Name of test material (as cited in study report): sodium salt of 2,4,-D acid
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- examined group:
8 male employees in section of 2,4-D acid production, aged 35-60 years (mean 48.5), duration of their employment: 15-39 years ( mean 26)
control group:
8 age-matched workers without exposure to 2,4-D acid
All participants were interviewed about demographic data, occupational history and life data that included smoking habit and other exposure to agents with known or suspected genotoxic activity.
Results and discussion
- Results:
- The difference between mean SCE frequency in the exposed and the control group was not statistically significant (α = 0.05)
In both groups, significant higher SCE frequencies were observed in lymphocytes of smokers.
These positive results for smokers demonstrate sufficient sensitivity of the used system.
Any other information on results incl. tables
Table 1a: Results of sister exchange frequency analysis in peripheral blood lymphocytes
of workers employed at production of 2,4-D acid of salt
Code No. |
Age (year) |
Employment (year) |
No. of cells |
No. of SCE |
Range SCE/cell |
Mean SCE/cell ± SD |
R/1* |
60 |
39 |
50 |
373 |
4 – 14 |
7.46 ± 2.29 |
R/2* |
60 |
29 |
50 |
421 |
3 – 18 |
8.42 ± 2.89 |
R/3* |
49 |
29 |
50 |
440 |
4 – 14 |
8.80 ± 2.53 |
R/4* |
44 |
25 |
50 |
442 |
4 – 20 |
8.84 ± 3.51 |
R/5 |
54 |
31 |
50 |
386 |
4 – 14 |
7.22 ± 2.95 |
R/6 |
42 |
22 |
50 |
372 |
3 – 12 |
7.44 ± 2.31 |
R/7 |
44 |
19 |
50 |
394 |
3 – 12 |
7.88 ± 2.45 |
R/8 |
35 |
15 |
50 |
410 |
4 – 14 |
8.20 ± 2.36 |
Mean |
48.5 |
26 |
|
|
|
8.10 ± 0.56 |
* - smokers
Table 1b: Results of sister exchange frequency analysis in peripheral blood lymphocytes of control subjects
Code No. |
Age (year) |
Employment (year) |
No. of cells |
No. of SCE |
Range SCE/cell |
Mean SCE/cell ± SD |
Rk/1* |
42 |
|
50 |
379 |
3 – 13 |
7.58 ± 2.70 |
Rk/2* |
42 |
|
50 |
396 |
3 – 12 |
7.94 ± 2.14 |
Rk/3* |
41 |
|
50 |
376 |
3 – 12 |
7.52 ± 2.20 |
Rk/4* |
56 |
|
50 |
498 |
4 – 18 |
9.96 ± 3.23 |
Rk/5* |
41 |
|
50 |
434 |
4 – 16 |
8.68 ± 2.46 |
Rk/6 |
63 |
|
50 |
349 |
3 – 13 |
6.98 ± 2.27 |
Rk/7 |
51 |
|
50 |
373 |
3 – 13 |
7.46 ± 2.68 |
Rk/8 |
39 |
|
50 |
384 |
3 – 15 |
7.68 ± 2.52 |
Mean |
47.6 |
|
|
|
|
7.98 ± 0.94 |
* - smokers
The mean cell SCE/cell for
Smokers (n=9): 8.35 ± 0.82
Non-smokers (n=7): 7.62 ± 0.38
Applicant's summary and conclusion
- Conclusions:
- Occupational exposure to 2,4-D acid did not produce a genotoxic effect measured by sister chromatid exchanges (SCE) in lymphocytes of examined workers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.