Registration Dossier
Registration Dossier
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EC number: 605-658-8 | CAS number: 173011-06-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptabele restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-hydroxyethoxy)propyl prop-2-enoate; 2-[2-[2-[2-(1-methyl-2-prop-2-enoyloxy-ethoxy)ethoxymethyl]butoxy]ethoxy]propyl 3-(dibutylamino)propanoate
- EC Number:
- 605-658-8
- Cas Number:
- 173011-06-8
- Molecular formula:
- Not specified UVCB - Reaction product of ethoxylated/propoxylated (0-6 EO; 0-6 PO) propylidenetrimethanol with acrylic acid and dibutylamine (acrylic acid : dibutylamine = 3:1)
- IUPAC Name:
- 2-(2-hydroxyethoxy)propyl prop-2-enoate; 2-[2-[2-[2-(1-methyl-2-prop-2-enoyloxy-ethoxy)ethoxymethyl]butoxy]ethoxy]propyl 3-(dibutylamino)propanoate
- Details on test material:
- - Name of test material (as cited in study report): Laromer LR 8864
- Physical state: liquid, colorless
- Analytical purity: 100 %
- Lot/batch No.: R /395
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, FRG
- Weight at study initiation: male: 2.78 kg; female: 2.66 kg
- Housing: 1 animal per cage
- Diet (e.g. ad libitum): Kliba 341, 130 g per animalper day
- Water (e.g. ad libitum): 250 ml tap water per animal per day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- male. 2
female: 1 - Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: four layers of absorbent gauze + porous bandage
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Remarks:
- 24 - 48- 72h
- Basis:
- mean
- Time point:
- other: 24 - 48- 72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Remarks:
- 24 - 48- 72h
- Basis:
- mean
- Time point:
- other: 24 - 48- 72h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72h
Any other information on results incl. tables
Readings:
Time |
Animal No. |
Erythema |
Edema |
4h |
1 |
0 |
0 |
2 |
0 |
0 |
|
3 |
1 |
0 |
|
24h |
1 |
1 |
0 |
2 |
0 |
0 |
|
3 |
1 |
0 |
|
48h |
1 |
1 |
0 |
2 |
0 |
0 |
|
3 |
0 |
0 |
|
72h |
1 |
0 |
0 |
2 |
0 |
0 |
|
3 |
0 |
0 |
|
Mean |
|
0.3 |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
