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EC number: 203-093-8 | CAS number: 103-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
It is concluded that test substance is a non-irritant to the rabbit's eyes and skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- N/A
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented, available information is sufficient for assessment.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- New Zealand white rabbits of both sexes (weighing 2.5 to 3.0 kg.) were used.
- Type of coverage:
- open
- Preparation of test site:
- other: abraded and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 5 g/kg bw
- Duration of treatment / exposure:
- 24hr
- Observation period:
- daily for 14 days
- Number of animals:
- 2
- Details on study design:
- The data obtained from acute oral LD50 studies in rats indicated relatively low toxicity of all test materials. Higher dosages were not used since LD50 values would have little meaning. Therefore, only one selected dose level of each compound was applied to a group of four rabbits of both sexes (weighing 2.5 to 3.0 kg). The dose site, approximately 240- cm2 (about 10% of body surface) was closely clipped. The skin of two of the animals was abraded and the skin of the two remaining animals was left intact. The skin was slightly moistened with physiological saline prior to application. Solid test materials were first ground to fine powders and then applied to the rabbit skin and covered with a nonabsorbent binder.
Animals were immobilized for 24 hours in stocks. Immediately following the removal of the binders, the local effects of the test compounds were scored according to the method of Draize. Toxic effects, dermal irritation, and mortality were recorded daily for 14 days. A necropsy was performed on each animal that died during the experiment and on those killed (by air embolism) at termination. Abnormal tissues and samples of adrenal, kidney, liver, lung, spleen, gonads, urinary bladder, bone, and skin were preserved in 10% formalin for possible histologic examination. - Irritation parameter:
- overall irritation score
- Remarks:
- intact and abraded skin
- Basis:
- mean
- Time point:
- other: 14day
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not relevant
- Remarks on result:
- other: scores were recorded gradually as none, very slight, well defined, moderate to severe and severe
- Irritation parameter:
- erythema score
- Remarks:
- abraded skin
- Basis:
- mean
- Time point:
- other: at all times
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant
- Remarks on result:
- other: scores were recorded gradually as none, very slight, well defined, moderate to severe and severe
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- other: at all times
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant
- Remarks on result:
- other: scores were recorded gradually as none, very slight, well defined, moderate to severe and severe
- Irritation parameter:
- edema score
- Remarks:
- abraded skin
- Basis:
- mean
- Time point:
- other: at all times
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant
- Remarks on result:
- other: scores were recorded gradually as none, very slight, well defined, moderate to severe and severe
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- other: at all times
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant
- Remarks on result:
- other: scores were recorded gradually as none, very slight, well defined, moderate to severe and severe
- Irritant / corrosive response data:
- There was no skin irritation to either intact or abraded skin following treatment with test substance.
- Other effects:
- There was no mortality observed during the test with methyl cinnamate. All animals appeared to be normal throughout the entire 14-day observation period. No gross pathologic findings occurred in the rabbit that were killed at termination.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, no dermal irritant effects were produced after administration of the undiluted test material to the intact or abraded skin of rabbits.
- Executive summary:
This study was conducted to investigate the acute dermal toxicity of test substance. Rabbits were applied at dosage level of 5 g/kg body weight. There was no mortality during the test. All animals appeared to be normal throughout the entire 14-day observation period. No gross pathologic findings occurred in the rabbits that were killed at termination. There was no skin irritation to either intact or abraded skin following treatment with test substance.
Therefore, undiluted test substance failed to cause skin irritation to rabbits during the test period.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- N/A
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented, available information is sufficient for assessment.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- New Zealand white rabbits of both sexes (weighing 2.3 to 3.4 kg.) were used.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eyes were used for control
- Amount / concentration applied:
- 3 mg
- Duration of treatment / exposure:
- N/A
- Observation period (in vivo):
- at 1, 4, 24, 48, 72 and 96 hours after dosing
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Six New Zealand albino rabbits, weighing 2.3 to 3.4 kg., were used to evaluate the irritating properties of each individual test material to the eye. Prior to application, the eyes were examined with the aid of fluorescein ophthalmic solution to confirm the absence of lesions in all eyes. One-tenth of one milliliter of the liquid or 3 mg. of the solid test material was instilled in one eye; the other eye, remaining untreated, served as control.
The ocular reactions to test materials were read post-treatment according to the Draize method at 1, 4, 24, 48, 72, and 96 hours and daily thereafter for a total of seven days (weekends excepted). At seven days, all eyes were reexamined with the aid of fluorescein ophthalmic solution. - Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0.17
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0.17
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.17
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- Under the conditons of the study, the test material produced conjunctival redness in 1/6 animals at 1, 4 and 24 hours only. 3 mg eye effects, irritant effects, conjunctival redness was observed in 1/6 animals at 1, 4 and 24 hours only, which cleared by 72 hours. No eye irritation was observed in animals receiving any of the test compounds at two hours.
- Other effects:
- No systemic toxic effects occurred in rabbits following the instillation of test substance.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results in this study, the test article methyl cinnamate caused no irritation to rabbits' eyes.
- Executive summary:
This report was published to evaluate the primary irritation of test substance to rabbits' eyes. One-tenth of one milliliter of the liquid or 3 mg. of the solid test material was instilled in one eye; the other eye, remaining untreated, served as control. The ocular reactions to test materials were read post-treatment according to the Draize method at 1, 4, 24, 48, 72, and 96 hours and daily thereafter for a total of seven days (weekends excepted). At seven days, all eyes were reexamined with the aid of fluorescein ophthalmic solution. No systemic toxic effects occurred in rabbits following the instillation of test substance. Under the condiitons of the study, the test material produced conjunctival redness in 1/6 animals at 1,4 and 24 hours only. 3 mg eye effects, irritant effects, conjunctival redness was observed in 1/6 animals at 1, 4 and 24 hours only, which cleared by 72 hours.
Therefore, it is concluded that test substance caused no irritation to rabbit's eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
One available report (report no. 2110) was published to evaluate the primary irritation of test substance to rabbits' eyes and skin. One-tenth of one milliliter of the liquid or 3 mg. of the solid test material was instilled in one eye; the other eye, remaining untreated, served as control. The ocular reactions to test materials were read post-treatment according to the Draize method at 1, 4, 24, 48, 72, and 96 hours and daily thereafter for a total of seven days (weekends excepted). At seven days, all eyes were re-examined with the aid of fluorescein ophthalmic solution. No systemic toxic effects occurred in rabbits following the instillation of test substance. Under the conditions of the study, the test material produced conjunctival redness in 1/6 animals at 1, 4 and 24 hours only. 3 mg eye effects, irritant effects,conjunctival redness was observed in 1/6 animals at 1, 4 and 24 hours only, which cleared by 72 hours and thus the very slight effects were fully reversible.
In addition, in this report, rabbits were applied dermally at dosage level of 5 g/kg body weight. There was no mortality during the test. All animals appeared to be normal throughout the entire 14-day observation period. No gross pathologic findings occurred in the rabbit that were killed at termination. There was no skin irritation to either intact or abraded skin following treatment with test substance.
Therefore, undiluted test substance failed to cause skin and eye irritation to rabbits during the test period.
Justification for classification or non-classification
Under the experimental conditions applied in a skin and an eye irritation study, methyl cinnamate is not to be classified according to CLP (Regulation EC No.1272/2008) or DSD (Directive 67/548/EEC) respectively. Data on respiratory irritation are not available.
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