Registration Dossier
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Diss Factsheets
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EC number: 239-816-9 | CAS number: 15721-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The toxicokinetic assessment is based upon the available data on bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine contained within this dossier. Data is taken from reliable sources, all rated as a 2 or higher for reliability and relevance according to the Klimisch scale as identified in Klimisch et al, 1997 scale. The toxicokinetic assessment is therefore considered reliable, based upon the information available.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The following information on bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine was used for the assessment:
Physical form: powder
Particle size: 404.691 µm (10% <52.296 µm)
Melting point: 98.9 ºC
Boiling point: >400 ºC
Water solubility: 0.1 mg/l at 20 ± 5 ºC
Log Pow: 8.8 at 35 ºC
Vapour pressure: <1.1E-05 Pa at 20 ºC and 25 ºC
Molecular weight: 393.6477
Hydrogen bond donors: 1
Hydrogen bond acceptors: 0
The particle size of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine indicates that it is unlikely to be absorbed via the inhalation route (less than 10% 10µm), and based upon the above information, bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not expected to be absorbed via the oral route in accordance with Lipinski's rule of five. The low water solubility and high Log Pow of the substance indicate that bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not easily absorbed in the body. No information is currently available on possible degradation products produced in the gastrointestinal tract. As bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is a solid powder with a very low water solubility (<0.1 mg/l), it is not expected to be absorbed via the dermal route.
During acute toxicity studies no systemic or local effects were noted at doses which humans are likely to come into contact.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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