Registration Dossier
Registration Dossier
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EC number: 235-428-9 | CAS number: 12225-21-7 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 19140:1.
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic sediments:
From BCFBAF Program (v3.00) model of EPI suite the estimated bio concentration factor (BCF) for test chemical aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate) (CAS No: 12225-21-7) is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that the test chemical aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate) is not expected to bio accumulate in the aquatic environment.
Additional information
Bioaccumulation: aquatic sediments:
Results of predicted data study for target compound aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate)(CAS No: 12225-21-7) and experimental study for its parent compound as read across chemical are summarized below for bioaccumulation in water and sediment endpoint.
In a key study prediction was done from BCFBAF Program (v3.00) model of Estimation Program interface Interface (EPI suite, 2017) in this study the estimated bio concentration factor (BCF) for test chemical aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate)(CAS No: 12225-21-7) was 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that the test chemical aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate) is not expected to bio accumulate in the aquatic environment.
Another study was supporting experimental study for parent compound of target chemical as read across chemical from authoritative database ( Jcheck, 2017) in this study the Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of read across chemical trisodium 5-hydroxy-1-(4-sulphophenyl)-4-(4-sulphophenylazo)pyrazole-3-carboxylate (CAS no 1934-21-0) on test organism Cyprinus carpio. Recovery ratio of Test water was at 1st concentration area: 91.7 % and at 2nd concentration area: 83 .0%, Fish: 90.6 %, and Limit of detection in Fish was 0.17 mg/L
Nominal concentrations used was 1st Concentration area: 0.6 mg/L (w/v), 2nd Concentration area: 0.06 mg/L (w/v) and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) ≥ 1000 ppm(w/v). The lipid content of fish was 2.8 %.
Thus according to static Fish test the BCF value for read across chemical trisodium 5-hydroxy-1-(4-sulphophenyl)-4-(4-sulphophenylazo)pyrazole-3-carboxylate was observed to be ≤0.29 L/kg at dose concentration 0.6 mg/L and ≤ 3 L/kg at dose concentration 0.06 mg/L on test organism Cyprinus carpio during 6 weeks period.These BCF values indicate that the read across substance trisodium 5-hydroxy-1-(4-sulphophenyl)-4-(4-sulphophenylazo)pyrazole-3-carboxylate is not bioaccumulative in fish and food chain as these values are far less than 2000 criteria.
On the basis of both the studies mentioned above it is concluded that test chemical aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate)(CAS No: 12225-21-7) is non bioaccumulative in nature.
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