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Diss Factsheets
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EC number: 940-417-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- testing starting date 1993-01-06; testing finishing date 1993-01-20; reporting date 1993-02-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically well performed study; Guideline study; GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
- EC Number:
- 940-417-3
- Molecular formula:
- C14H30O4 C16H34O5
- IUPAC Name:
- 5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material :Triethylenglykoldibutylether
- CAS: 63512-36-7
- Molecular formula : C14H30O4
- Molecular weight : 263 g/mol
- Physical state: liquid
- Storage condition of test material: in darkness at room temperature under chemical fume hood
- Solubility: 2g/L in water
- Melting point: -42 °C
- Boiling point: 283 °C
- Density: 0.9169 mg/l at 20 °C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% (weight/volume)
- Amount of vehicle (if gavage): 10 mg/kg - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Unspecific toxicity observed on day of application. No further effects were observed.
Any other information on results incl. tables
On day of application the treated animals responded with unspecific intoxication signs. These included increased respiration rate, irregualr respiration, stupor, coat bristling, flanks drawn in, stilted gait, ataxic gait, prone position, squatting posture, clonic convulsions, trembling, fissure narros, narcosis, no corneal reflex, reduced pawreflex to pincing, no pawreflex to pinching, no lacing reaction and creased spontaneous activity. All these effects disappeared within 24 hours. The treated animals exhibited normal body weight development in the observation period of 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No classification is assigned for the registration substance for the endpoint acute oral toxicity.
- Executive summary:
The acute oral toxicity of the registration substance was investigated according to the OECD Guideline 401. 5 male and 5 female rats were treated with triethyleneglycoldibutylether (representative material for the registration substance) at dose of 2000 mg/kg bw via gavage. No mortality occured. On the application day unspecific toxicity signs were observed, which disappeared within 24 hours. The treated animals exhibited normal body weight development in the observation period of 14 days. The acute oral toxicity of the registration substance is found to be of no concern.
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