Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-823-0 | CAS number: 10377-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Concerning skin irritation, there is one GLP guideline study available with trilithium orthophosphate itself (BASF 2012), revealing no skin irritating properties of the test substance.
With regard to this endpoint, the lithium ion is considered to be the main toxophore, as phosphate ions are widely distributed throughout the organism (e.g. as structural material of bone and teeth and in form of adenosine phosphates ADP and ATP).
With regard to the fact, that trilithium orthophosphate is slightly soluble in water (0.27 g/L), read-across to a more soluble lithium salt (representing a higher bioavailability) can be justified. However, for the endpoint "eye irritation", read-across was also performed to another alkali phosphate (Trisodium orthophosphate).
There is one study summary for Lithium chloride (CAS# 7447-41-8) publicly available on the homepage of the ECHA (European Chemicals Agency; disseminated dossier for Lithium chloride). This study was performed according to OECD Guideline 404. It is concluded that the test material is not irritating according to GHS criteria.
Another study summary for Lithium carbonate (CAS# 554-13-2; disseminated dossier for Lithium chloride; ECHA homepage) is publicly available and the overall conclusion of this study (according to OECD TG 404) is, that the test material is not irritating to skin according to GHS criteria.
For the endpoint “eye irritation”, read-across was performed to Lithium chloride (CAS# 7447-41-8), Lithium carbonate (CAS# 554-13-2) and to trisodium orthophosphate (CAS# 7601-54-9). All the information is publicly available on the ECHA homepage (disseminated dossiers for Lithium chloride, Lithium carbonate and trisodium orthophosphate). Lithium chloride and Lithium carbonate are considered to be irritating to eyes (Cat. 2) according to GHS criteria. Trisodium orthophosphate is considered to be an eye irritant under the grading system as outlined in the Federal Substances Labelling Act.
Based on a GLP guideline study in vitro (BASF 2012), trilithium orthophosphate is not classified for skin irritation. Trilithium orthophosphate is classified as Xi, R36, irritating to eyes in accordance to Directive 67/548/EEC; Eye irritation Cat. 2A, H319, causes serious eye irritation in accordance to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.