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Diss Factsheets
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EC number: 201-911-8 | CAS number: 89-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: non-GLP and not OECD compliant study
Data source
Reference
- Reference Type:
- publication
- Title:
- Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives
- Author:
- Tokuoka Y, Suzuki M, Ohsawa Y, Ochiai A, Ishizuka M, Kawashima N
- Year:
- 2 008
- Bibliographic source:
- PMID:18568909 Drug Dev Ind Pharm 34(6):595-601
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Enhancing effect of l-menthyl acetate on skin permeation of 5-aminolevulinic acid (ALA) through Yucatan micropig full-thickness skin using a Franz-type diffusion cell
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthyl acetate
- EC Number:
- 201-911-8
- EC Name:
- Menthyl acetate
- Cas Number:
- 89-48-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 5-methyl-2-(propan-2-yl)cyclohexyl acetate
Constituent 1
- Radiolabelling:
- no
Results and discussion
Any other information on results incl. tables
Over 16 h the cumulative amount of 5-aminolevulinic acid (ALA) is obviously the largest in the case of l-methyl acetate.
This would be caused by the small difference in inorganic/organic value ratio (0.33), or hydrophobicity of terpene. Permeability coefficient increased with decreasing inorganic/organic value ratio, or with increasing hydrophobicity of l-menthol and his derivative, reaching the maximum in the system with l-menthyl acetate. This finding suggests that l-menthyl acetate has the optimal hydrophobicity of l-menthol derivative for enhancing ALA skin permeation.
Applicant's summary and conclusion
- Conclusions:
- l-menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.
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