Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-837-2 | CAS number: 13001-46-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Well documented and conducted study.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Oral toxicity of xanthates
- Author:
- Kirk-Othmer Encyclopaedia of Chemical Technology
- Year:
- 1 984
- Bibliographic source:
- Vol 24, 2nd ed, pp 645-661, John Wiley & Sons, 1984.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Reference Type:
- review article or handbook
- Title:
- Priority existing chemical Report No. 5
- Author:
- Dep. of Health and Ageing, Australian Government
- Year:
- 1 995
- Bibliographic source:
- National Industrial Chemicals Notification and Assessment Scheme
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Sodium O-isobutyl dithiocarbonate
- EC Number:
- 246-805-2
- EC Name:
- Sodium O-isobutyl dithiocarbonate
- Cas Number:
- 25306-75-6
- IUPAC Name:
- sodium O-isobutyl dithiocarbonate
- Reference substance name:
- Sodium isobutyl xanthate
- IUPAC Name:
- Sodium isobutyl xanthate
- Test material form:
- solid: compact
- Details on test material:
- - Name of test material (as cited in study report):Sodium isobutyl xanthate
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-265g
- Fasting period before study: Over night
- Housing: Group housing (5 of each sex per cage), in metal cages provided with white pine and cheddar shavings.
- Diet: Purina Laboratory Chow, ad libitum.
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Exploratory doses were administered to 8 rats to estimate the order of toxicity of the test compound. Based on the preliminary estimation, groups of 10 rats (5M, 5F) were administered the test compound at graded dosage levels designed to blanket the toxicity range. - Doses:
- 500,2000 mg
- No. of animals per sex per dose:
- 5 female, 5 male
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Regular intervals on the day of dosing and daily thereafter for 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Gross necropsies were performed on all survivors and any animals which died during the observation period. Body weights of survivors were recorded prior to sacrifice.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The findings of this study indicate that Sodium Isobutyl Xanthate produces adverse effects on the central nervous system, liver and kidneys.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The findings of this study indicate that Sodium Isobutyl Xanthate produces adverse effects on the central nervous system, liver and kidneys.
- Mortality:
- All death occurring 1 to 2 hours after administration.
- Clinical signs:
- other: Oral administration of Sodium Isobutyl Xanthate to rats produced increased motor activity, cyanosis, irritability, increased respiration and convulsions with death occurring 1 to 2 hours after administration.
- Gross pathology:
- Autopsy showed perivascular and pericellular oedema, multiple haemorrhages in the lungs, perivascular subarachnoid haemorrhages and acute
swelling of the cells of the cortex, subcortical ganglia and the brain stem. Fatty dystrophy of the liver and protein dystrophy of the twisted canaliculi of the
kidneys were observed. - Other findings:
- The findings of this study indicate that Sodium Isobutyl Xanthate produces adverse effects on the central nervous system, liver and kidneys.
Any other information on results incl. tables
Table 3: |
Oral toxicity of xanthates (from: Kirk-Othmer, 1984)16 |
||||||
Xanthate |
Species |
LD0 |
(mg/kg) |
LD50 |
(mg/kg) |
References |
|
Sodium ethyl |
rat |
500 |
— |
17 |
|||
Potassium ethyl |
Rat mouse |
500 |
1700 583 |
17, 18 |
|||
Sodium isopropyl |
rat |
250 |
— |
17 |
|||
Potassium isopropyl |
rat mouse |
— — |
1700 583 |
18 — |
|||
Potassium n-butyl |
mouse |
— |
411 465 |
19,20 |
|||
Sodium isobutyl |
rat |
|
500 |
17 |
|||
Potassium isobutyl |
rat mouse |
— — |
1290 480 |
18 18 |
|||
Sodium sec-butyl |
rat |
— |
>2000 |
17 |
|||
Potassium amyl (mixed) |
rat |
1000 |
1000–2000 |
17, 21 |
|||
Potassium iso amyl |
rat mouse |
— — |
765 470 |
18 18 |
|||
C5-C6 mixture |
rat |
— |
1500 |
22 |
|||
The LD50 value of 500 mg/kg was determined for Sodium Isobutyl Xanthate. This show that Sodium Isobutyl Xanthate is of a moderately order of acute oral toxicity .
The LD50 of the various xanthates are similar, ranging from 411 to 583mg/kg in mice and from 1000 to >2000 mg/kg in rats.
The acute oral toxic effects of one xanthate, potassium butyl xanthate, are providedin two summaries in Chemical Abstracts.
Similar symptoms and pathologyfindings were seen in these studies carried out by Babayan.
References :
16.Kirk-Othmer Encyclopaedia of Chemical Technology,Vol 24, 2nd ed, pp 645-661,John Wiley & Sons, 1984.
17.Dow Chemical Company, 1964, unpublished toxicological data to C.B. Shaffer,American Cyanamid; data from P. Avotin, American Cyanamid, privatecommunication, 1982 as cited in Kirk-Othmer Encyclopaedia of Chemical
18.Babayan, E.A., 1963, “Toxicology of Potassium Butyl Xanthate” Material 2-oi[Vtoroi] Itog. Nauchn. Konf. Inst. Gigieny Truda I Prof. Zabolevan Posvyashch.Vopr. Gigieny Truda I Prof. Patol. Erevan, pp 75-77 (Pub 1964)(Russ)Chem Abstract,64, 8836e (1966).
19.Babayan, E.A., “Toxicological Characteristics of the Flotation Agent PotassiumButyl Xanthate”, Mater. Itogovoi Nauch. Konf. Vop. Gig Tr Profpatol. Khim.Gornorud. Prom., 3rd 1966 (Pub 1968) 97-102 (Russ) inChemical Abstracts,Vol 73,1970.
20.Fronk, N.G., The Dow Chemical Company, private communication, 1982, as cited inKirk-Othmer Encyclopaedia of Chemical Technology,Vol 24, 2nd Ed, pp 645-661,John Wiley & Sons, 1984.
21.Buzina, A.Z., Burkhanov, A.I. and Abeuev, Kh.B., 1977 Zdravookhr. Kaz., 88 ascited inKirk-Othmer Encyclopaedia of Chemical Technology,Vol 24, 2nd Ed, pp645-661, John Wiley & Sons, 1984.
22.Chemical Abstracts,Vol 64, 1966.
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value of 500 mg/kg was determined in a reliable study. The Potassium isobutyl xanthate (CAS No. 13001-46-2), the subject of this dossier) is expected to exhibit very similar toxicity to Sodium isobutyl xanthate (CAS No. 25306-75-6),)), which is also isobutyl compound. Comparable metabolism would occur.This show that the substance is of a moderately order of acute oral toxicity .
Based on the data provided in this review, Potassium Isobutyl Xanthate shall be classified for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.