Registration Dossier
Registration Dossier
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EC number: 231-293-5 | CAS number: 7486-38-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1937
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP but overall good documentation; only one dog used. Breath not analysed, purity not specified, reliability of detection method unclear
Data source
Reference
- Reference Type:
- publication
- Title:
- Stoffwechselversuche mit Dicarbonsaeuren.
- Author:
- Bernhard K, Andreae M (
- Year:
- 1 937
- Bibliographic source:
- Hoppe-Seylers Z. physiol. Chem. 245, 103-106.
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- One dog was fed a sodium adipate containing diet. 1. Experiment: 1 g compound, twice a day, 5 days (=150 mg/kg bw/day, total 10 g). 2. Experiment: 5 g compound, twice a day, 7 days (=750 mg/kg bw/day, total 70 g). Urine was collected and the dose of adipic acid in the urine was determined
- GLP compliance:
- no
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- dog
Administration / exposure
- Route of administration:
- oral: feed
- No. of animals per sex per dose / concentration:
- Females: 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: 18% adipic acid was recovered unchanged in the low dose experiment and 63.6% in the high dose experiment
Any other information on results incl. tables
RS-Freetext:
18% adipic acid was recovered unchanged in the low dose experiment and
63.6% in the high dose experiment
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
