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EC number: 244-842-9 | CAS number: 22205-45-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification of the read-across from copper (II) oxide to dicopper sulphide:
In order to minimise animal testing, data on the acute dermal toxicity, eye irritation and sensitisation potential of copper(II) oxide have been read across to dicopper sulphide (copper (II) oxide is unclassified on the basis of acute toxicity, irritation and sensitisation potential). These are both simple inorganic copper compounds with low water solubility and an anion of no toxicological concern. In fact, theoretical estimates for the solubility of dicopper sulphide are orders of magnitude lower than those of the oxide, ranging from 3.43E-10 µg/L to 1.36E-08 µg/L. It is generally accepted that lower water solubility can be equated to lower bioavailability and hence acute toxicity; an effect clearly seen by a comparison of copper(II) oxide toxicity with that of the more soluble copper(I) oxide. On this basis, it is considered that a read-across of the acute toxicological, irritation and sensitisation properties from copper(II) oxide to dicopper sulphide represents a reasonable worst-case approach, and leads to that conclusion that dicopper sulphide is similarly unclassified. This conclusion is supported by the fact that acute oral toxicity (Bradshaw, 2012) and skin irritation testing (Warren, 2012) carried out with dicopper sulphide confirms that this compound is unclassified for these endpoints.
Skin irritation/corrosion:
A GLP-compliant in-vitro skin irritation test was conducted in accordance with the requirements of OECD Guideline 439 and EU Method B.46 (Warren, 2012). Data were presented in the form of percentage viability. The relative mean viability of the test item treated tissues was 57.6% after a 15 minute exposure. On this basis it is concluded that dicopper sulphide is unclassified on the basis of skin irritation/corrosivity potential. This conclusion is supported by the results of a GLP-compliant skin irritation/corrosivity study conducted in the rabbit with the read-across compound copper (II) oxide in accordance with OECD Guideline 404 (Sanders, 2002c). No erythema or oedema was recorded in any animal at any time.
Eye irritation/corrosion:
A GLP-compliant eye irritation study was conducted in New
Zealand White rabbits with the read-across compound copper (II) oxide in
accordance with OECD Guideline 405 (Sanders, 2002d). Average scores for
corneal opacity, iris, conjunctival redness and chemosis were 0.33,
0.22, 0.77 and 0.55 respectively. All effects were fully reversible. It
is therefore concluded that dicopper sulphide is not classified on the
basis of eye irritation/corrosivity.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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