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EC number: 206-526-9 | CAS number: 352-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- dimethyl sulphide (CAS # 75-18-3)
- IUPAC Name:
- dimethyl sulphide (CAS # 75-18-3)
- Details on test material:
- No data available.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Mice weighting about 20g were exposed to an atmosphere containing gaseous DMS in a desiccator. Five different concentrations of DMS gas were investigated and 5 mice were used for each group. Liquid DMS was placed in the bottom of the desiccator which was immediately covered with a lid. The underside was warmed to 40°C in a water bath to vapourize the DMS and the gas mixed with air from the atmosphere with a stirring bar. As DMS was vapourized, the lid was raised slightly by the expanded atmosphere, some of which over-flowed from the desiccator. After the overflow had ceased the lid was opened slightly, a mouse was inserted into the atmosphere and the lid was closed immediately. A small amount of the atmosphere was sampled to determine the concentration of DMS in the atmosphere by inserting a micro-syringe through the adhesive vinyl tape closing a small outlet at the side of the desiccator. The behaviour of the mouse after exposure to the atmosphere was observed and the time elapsed until changes in gait and respiratory arrest were also noted. After death had occurred. The atmosphere was sampled again to determine the concentration of DMS in the atmosphere.
- Duration and frequency of treatment / exposure:
- Single exposure until death
Doses / concentrations
- Remarks:
- Doses / Concentrations:
6.8, 11.6, 23.6, 34.0 and 50.6%
- No. of animals per sex per dose / concentration:
- 5
- Control animals:
- no
- Details on study design:
- Blood and issue samples were taken, weighed, sealed in class vials and stored at -20°C until quantification of the DMS content was carried out.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- DMS was distributed in all tissues of the mice at levels of 0.05-12.9 mg/g with an average of 2.34 mg/g. At a concentration of 6.8 ± 1.3%, DMS was distributed in every tissue almost equally except for the lungs where the concentration was much lower. At concentrations of 11.6 ± 0.5%, 23.6 ± 3.7% and 34.0 ± 3.1 % distribution patterns were almost the same. At a concentration of 30.6 ± 3.6%, DMS was distributed in lung, blood, heart muscle and brain at similar levels to those at 6.8%.
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
Table 1: Distribution of dimethyl sulphide (DMS) in tissues of mice exposed to an atmosphere containing DMS
Tissue |
DMS (%) |
||||
6.8 ± 1.3 |
11.6 ± 0.5 |
23.6 ± 3.7 |
34.0 ± 3.1 |
50.6 ± 3.6 |
|
Lung |
0.19 ± 0.21 |
2.90 ± 1.57 |
1.66 ± 0.73 |
2.12 ± 0.44 |
0.29 ± 0.32 |
Blood |
0.76 ± 0.16 |
5.34 ± 0.94 |
2.30 ± 0.38 |
4.54 ± 1.91 |
0.96 ± 0.29 |
Heart Muscle |
1.20 ± 0.72 |
3.96 ± 1.16 |
4.06 ± 1.36 |
3.78 ± 0.88 |
1.42 ± 0.36 |
Brain |
1.16 ± 0.36 |
9.12 ± 2.77 |
8.22 ± 3.80 |
8.00 ± 2.92 |
0.88 ± 0.32 |
Liver |
1.28 ± 0.74 |
4.50 ± 1.33 |
2.10 ± 0.97 |
2.24 ± 0.50 |
0.20 ± 0.09 |
Spleen |
0.40 ± 0.18 |
2.30 ± 0.99 |
1.20 ± 0.47 |
1.48 ± 0.50 |
0.20 ± 0.09 |
Kidney |
1.10 ± 0.34 |
3.62 ± 0.67 |
1.60 ± 1.08 |
1.94 ± 0.55 |
0.48 ± 0.13 |
Muscle |
0.92 ± 0.55 |
1.52 ± 0.71 |
1.06 ± 0.26 |
2.14 ± 1.05 |
0.38 ± 0.10 |
Applicant's summary and conclusion
- Executive summary:
Following single acute exposure of mice to atmospheres of dimethyl sulfphide vapors from 6.8% to 50.6% (w/v), dimethyl sulphide was distributed in all tissues almost equally, except for the lungs where the concentration was much lower (Terazawa et al., 1991).
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