Registration Dossier
Registration Dossier
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EC number: 219-739-7 | CAS number: 2516-96-3
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
There are no many data available on 2-chloro-5-nitrobenzoic acid, thus a read across on structural analogues approach has been evaluated in order to outline an (eco)toxicological profile most complete as possible and to elaborate an appropriate C&L.
Substances considered for read across are 4-chloro-3-nitrobenzoic acid (CAS: 96-99-1; EC: 202-550-9) and 3-nitrobenzoic acid (CAS: 121-92-6; EC: 204-508-5).
Considering all data available, it is expected that 2-chloro-5-nitrobenzoic acid is a skin sensitizer (Skin Sens 1, H317) and an eye irritant (Eye Irrit. 2, H319).
Both eye irritation and skin sensitization were evaluated through the comparing with the outcomes on the analogue 4 -chloro-3 -nitrobenzoic acid. In the first case substance showed adverse effects lasting more than 21 days as moderate redness, swelling of the conjunctiva, reddening of the iris and corneal cloudiness. In the case of skin sensitization, it was evaluated by Mouse Local Lymphnode Assay (LLNA) test that resulted positive.
No concern for acute and repeated dose toxicity has been reported.
Mutagenicity was investigated by both in vitro and in vivo tests: in the first case some positive results were reported, but they were not confirmed by the in vivo outcomes, that reported no genetic toxicity effects.
In the studies on reproductive toxicity some adverse effects on fertility were observed; nevertheless it has to be considered that substance was tested at dosage so high that a reliable conclusion can not be drawn.
Any details about data available are reported in the report attached at the point 13: Assessment Report.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
There are no concern for genaral population. because 2-chloro-5-nitrobenzoic acid is a pharmacautical intermediate, thus it is not expected that a contact with the substance can occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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