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EC number: 242-894-7 | CAS number: 19224-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key data is available for propylene glycol dibenzoate (PGDB). This data is supported by relevant information available from a structural analogue Dipropylene glycol dibenzoate (DPGDB). The justification for read across is provided as an attachment included in Section 13 of the IUCLID dossier.
Short-term toxicity to fish
Based on the prediction results, propylene glycol dibenzoate was predicted to have a fish LC50 of 3.7 mg/L after 96 hours exposure (ester class toxicity) (US EPA, 2012; Klimisch Score = 2).
The 96 h LC50 value for DPGDB with fathead minnow was determined 3.7 mg/L. The "no-observed effect concentration" (NOEC) for DPGDB with fathead minnow was determined to be 1.2 mg/L (Huntingdon Life Sciences, 2000a; Klimisch score = 1).
The 96 h LC50 value for DPGDB with rainbow trout was >3.0 mg/L. The "no-observed effect concentration" (NOEC) for DPGDB with rainbow trout was 3.0 mg/L (Huntingdon Life Sciences, 2000b; Klimisch score = 1).
These values are supported by the QSAR modelling (US EPA, 2009; Klimisch score = 2) with a 96-hour LC50 value of 3.94 mg/L for DPGDB.
Long term toxicity to fish
A Guideline OECD 210 fish early-life stage toxicity study has been proposed for the structural analogue dipropylene glycol dibenzoate (DPGDB) and will be read across to once the study results are available.
Short-term toxicity to aquatic invertebrates
Propylene glycol dibenzoate is predicted to have LC50’s of 4.325 mg/L (baseline toxicity) and 6.387 mg/L (Ester class) after 48 hours exposure to Daphnid (US EPA, 2012; Klimisch score = 2).
In an acute Daphnia Immobilisation GLP study conducted according to EC, OECD, and US EPA test guidelines (Huntingdon Life Sciences, 2001a; Klimisch score = 1), the 48 hour EL50 (immobilisation value with Daphnia Magna) for dipropylene glycol dibenzoate was determined to be 19.3 mg/L. The "no-observed effect loading rate" (NOELR) was 2.2 mg/L.
Long-term toxicity to aquatic invertebrates
There are no key data available for propylene glycol dibenzoate (PGDB). Data available from a structural analogue Dipropylene glycol dibenzoate (DPGDB) has been used to read-across to PGDB to fill this requirement. The justification for read across is presented as an attachment included in Section 13 of the IUCLID dossier.
In a 21 -day Daphnia reproduction GLP study conducted according to OECD 211 a NOEC (reproduction and growth) of 2.2 mg/l (based on the measured geometric mean) was reported (Smithers Viscient; Klimisch score = 1).
Toxicity to aquatic algae and cyanobacteria
In a GLP, OECD Guideline 201 study in unicellular green alga Pseudokirchneriella subcapitata, the NOEC and 72 hr EC50 growth rate for propylene glycol dibenzoate was determined to be 0.298 and 1.53 mg/L, respectively (Huntingdon Life Sciences, 2015a; Klimisch score = 1).
Propylene glycol dibenzoate was predicted to have LC50’s of 6.243 mg/L (baseline toxicity) and 2.066 mg/L (Ester class) after 96 hours exposure to green algae (US EPA, 2012; Klimisch score = 2).
In a GLP algal growth inhibition conducted according to EC, OECD 201, and US EPA test guidelines, the EL50 (Area under the curve 72 h) for dipropylene glycol dibenzoate was 1.1 mg/L and the EL50 (Growth rate 0 - 72 h) was 4.9 mg/L. The corresponding "no-observed effect loading rates" (NOELR) were 0.22 and 1.0 mg/L, respectively. The EL50 (Area under the curve 96 h) was 0.95 mg/L and the EL50 (Growth rate 0 - 96 h) was 3.6 mg/L. A NOELR could not be obtained for Area under the curve 96 h, the NOELR for growth rate was 0.46 mg/L (Huntingdon Life Sciences, 2001b; Klimisch score = 1).
Toxicity to microorganisms
A GLP, OECD Guideline 209 study activated sludge respiratory inhibition test was performed with propylene glycol dibenzoate. The EC50 was found to be >1000 mg/L and NOEC was determined to be 100 mg/L (Huntingdon Life Sciences, 2014d; Klimisch score = 1).
Two studies conducted according to international guidelines and in compliance with GLP, are available for DPGDB. The activated sludge respiration inhibition test demonstrated a NOEC ≥ 100 mg/L, the highest concentration tested (Huntingdon Life Sciences, 1998d; Klimisch score = 1). The assay on growth of the bacteria Pseudomonas putida demonstrated a NOEC ≥ 10 mg/L (Safepharm Laboratories Ltd.,1998a, Klimisch score = 1).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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