Registration Dossier
Registration Dossier
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EC number: 205-187-4 | CAS number: 135-37-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No data for EDG are available. However, Arthur et al (1974) presents 21 week NOEC results of 9.3 mg/L with the structurally comparable NTA for survival for the amphipod, Gammarus pseudolimnaeus . Recalculated to EDG (mol weight ratio) would give 7.5 mg/L EDG (molweight EDG/NTANa3.H20 = 221/275 x 9.3). This value is supported by the chronic toxicity study with a snail (Flannagan, 1974).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 7.5 mg/L
Additional information
Arthur et al (1974) presents 21 week NOEC results of 9.3 mg/L Na3NTA for survival and 19 mg/L Na3NTA for reproduction for the amphipod, Gammarus pseudolimnaeus. Study was performed by exposing 18 day old amphipods to measured concentrations of Na3NTA for 21 weeks. Mortality and reproduction were assessed. However, control survival was only 56% which does not meet validity requirements.
The 21 week NOEC (survival) would correspond to 7.5 mg/L EDG.
In addition, Flannagan (1974) exposed snails (Helisoma trivolvis) to Na3NTA concentrations for 120 days resulting in a NOEC of 12.5 mg/L Na3NTA. Due to the age of this study, some testing information is missing and it was not possible to fulfill a robust study summary. Results of both Arthur et al. (1974) and Flannagan (1974) studies are within the same range and can be used as weight of evidence in predicting the toxicity of Na3NTA to aquatic invertebrates.
Canton and Slooff (1982) provided 21 -day NOEC of 100 mg/L, based on mortality and reproduction, for Daphnia magna. However, this study is considered unreliable due to lack of testing information.
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