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Diss Factsheets
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EC number: 205-533-4 | CAS number: 142-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication describing a test method which meets basic scientific principles. Some limitations in design and reporting but outcome considered reliable and adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Principles of method if other than guideline:
- Algal inoculum (Pseudokirchneriella subcapitata, formerly known as Selenastrum capricornutum, UTEX 1648) was withdrawn from chemostat operated under steady state and transferred into 300 mL, biochemical-oxygen-demand (BOD) test bottles together with dilution water (with growth medium) and toxicants. The BOD bottles were filled completely with no headspace left. A water seal was provided to ensure a closed test environment. The bottles were then placed on an orbital shaker. Temperature and light intensity were kept at 24 ± 1°C and 65 µE·m-2·s-1 (±10%}, respectively. US EPA bottle medium, with no EDTA content, was used for toxicity testing. Two response endpoints were used to evaluate the toxicity of the toxicants: the final yield (final cell density- initial cell density) and algal growth rate based on cell density counts. The initial inoculated cell density was 15000 cells per mL, which was determined using an electronic particle counter. The initial pH for toxicity testing was set at 7.5. Thirty-four propargylic alcohols, including primary, primary homo-, secondary, and tertiary alcohols, were tested in the present study. All chemicals used were of reagent grade and were tested at least twice, i.e. , range finding test and definitive test. For the definitive test, one control and 6 (or 7) different treatments were performed in triplicate. Stock solution was freshly prepared, and its concentration was analyzed with a total organic carbon (TOC) analyzer before commencing the experiment. Toxicants with low solubility were dissolved in dimethyl sulfoxide (DMSO). Solvent controls were conducted using the highest DMSO concentration applied in treatments.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,5-dimethylhexyne-2,5-diol
- EC Number:
- 205-533-4
- EC Name:
- 2,5-dimethylhexyne-2,5-diol
- Cas Number:
- 142-30-3
- Molecular formula:
- C8H14O2
- IUPAC Name:
- 2,5-dimethylhex-3-yne-2,5-diol
- Details on test material:
- - Name of test material (as cited in study report): 2,5-Dimethyl-3-hexyne-2,5-diol
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- - Strain: UTEX 1648
Study design
- Test type:
- static
- Water media type:
- freshwater
Results and discussion
Effect concentrationsopen allclose all
- Dose descriptor:
- EC50
- Effect conc.:
- 2 098.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: No test duration is specified.
- Dose descriptor:
- EC10
- Effect conc.:
- 193.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: No test duration is specified
- Reported statistics and error estimates:
- Probit analysis was applied to determine the concentration response relationship and the median effective concentration (EC50). One-tail Dunnett's procedure was applied for the calculation of NOEC and LOEC values at 5% Ievel of significance.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.