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Diss Factsheets
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EC number: 226-641-8 | CAS number: 5444-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Acute toxicity: Oral LD50 (rat, m/f): > 2500 mg/kg bw (OECD 423)
Acute toxicity: Dermal LC50 (rat, m): > 5000 mg/kg bw (OECD 402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Oral
The acute oral toxicity of 2-ethylhexyl benzoate was evaluated in rats in accordance with OECD guideline 423 under GLP conditions (Blanchard, 2000).
Sprague-Dawley rats (males and females) were stepwise dosed with the test material (5000 and 2000 mg/kg bw) using three animals of a single sex per step.
At 5000 mg/kg bw 1/3 females and 2/3 males died 48 h post-dose. In the next step at 2000 mg/kg bw only one female animal died (72 h post-dose). All animals showed clinical signs of abnormal gait and hunched posture and further signs were apparent in single animals e.g. lethargy, reduced body temperature being fully reversible within 3 days.
Reduced body weight was observed in one female at 2000 mg/kg bw on Day 8 only.
Necropsy revealed no substance-related findings.
Therefore, the oral LD50 for male and female rats was considered to be 2500 mg/kg bw according to the cut off values of OECD guideline 423.
Inhalation
This information is not available.
Dermal
The acute dermal toxicity of 2-ethylhexyl benzoate was evaluated according to OECD guideline 403 under GLP conditions (Blanchard, 2000).
A group of five Sprague-Dawley rats (males and females) were treated in a limit test with 5004 mg/kg bw of the test substance.
No mortality occurred during the study period in any animal. No systemic clinical signs of toxicity were observed up to the end of the 14-day observation period. Transient very slight dermal irritation was seen in all animals following removal of the dressing, resolving completely by Day 4.
A loss in body weight was recorded for one female and low body weight gains were noted for the 4 remaining females on Day 8. All other animals were considered to have achieved satisfactory body weight throughout the study.
Necropsy revealed no substance-related findings.
Therefore, the dermal LD50 for male and female rats was considered to be greater than 5000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Only one study available.
Justification for selection of acute toxicity – dermal endpoint
Only one study available.
Justification for classification or non-classification
The available data on acute toxicity of 2-ethylhexyl benzoate do not meet the criteria for classification according to Regulation (EC) 1272/2008, and the data are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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